Extending the models for XX and XO data, so as to keep a consensus network as far as possible.
Steps to find the common link to be added :
1.) Read in the extension.csv for both cell lines
2.) Remove links from TFs and Ligands
3.) Retain only links that have adjusted p-value < 0.01 and value !=0
4.) Calculate %improvement in residual for each cell line
5.) Find the intersection list,(Links that appear in both lists)
6.) Calculate the sum of %improvement in residual
7.) Order the intersection list by descending order of sum of %improvement in residual.
8.) Add the link with Max sum of %improvement to both models.
XX
Initial-Fit

Model residual = 2056





Link Extension :
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
|
1
|
178
|
Gsk3
|
Igfr
|
3.13276929030024
|
1280.86163056012
|
18
|
775.439838991864
|
2
|
0
|
0
|
|
2
|
171
|
Gsk3
|
Akt
|
2.00744510484014
|
1288.7198924196
|
18
|
767.581577132387
|
2
|
0
|
0
|
|
3
|
183
|
Gsk3
|
Pi3k
|
28.3512885413349
|
1289.13235441924
|
18
|
767.169115132742
|
2
|
0
|
0
|
|
4
|
176
|
Gsk3
|
Fgfr
|
0.191531853873651
|
1372.05906797687
|
18
|
684.242401575108
|
2
|
0
|
0
|
|
5
|
409
|
Stat3
|
Igfr
|
0.997104946770457
|
1503.11324672765
|
17
|
553.188222824328
|
1
|
0
|
0
|
|
6
|
220
|
Jak
|
Igfr
|
0.0748374592692973
|
1503.11324675228
|
17
|
553.188222799702
|
1
|
0
|
0
|
|
7
|
407
|
Stat3
|
Fgfr
|
0.300461971006367
|
1515.31854390064
|
17
|
540.982925651346
|
1
|
0
|
0
|
|
8
|
218
|
Jak
|
Fgfr
|
0.0226288712947294
|
1515.31854402861
|
17
|
540.982925523376
|
1
|
0
|
0
|
|
9
|
225
|
Jak
|
Pi3k
|
0.694735352806384
|
1519.02257775189
|
17
|
537.278891800091
|
1
|
0
|
0
|
|
10
|
414
|
Stat3
|
Pi3k
|
9.22290789883903
|
1519.02257776675
|
17
|
537.278891785232
|
1
|
0
|
0
|
|
11
|
402
|
Stat3
|
Akt
|
0.536042655056134
|
1523.34265168251
|
17
|
532.958817869469
|
1
|
0
|
0
|
|
12
|
213
|
Jak
|
Akt
|
0.0402569717690179
|
1523.34265168778
|
17
|
532.958817864204
|
1
|
0
|
0
|
|
13
|
92
|
Bmp4r
|
Fgfr
|
10.0076490483583
|
1854.77447563085
|
18
|
201.526993921128
|
2
|
0
|
0
|
|
14
|
386
|
Smad2
|
Fgfr
|
-2.41655006670941
|
1894.64741116463
|
17
|
161.65405838735
|
1
|
0
|
0
|
|
15
|
29
|
Actr
|
Fgfr
|
-0.792491707221983
|
1894.64741116818
|
17
|
161.654058383804
|
1
|
0
|
0
|
|
16
|
8
|
Activin
|
Fgfr
|
-0.792537854853646
|
1894.64741119847
|
17
|
161.654058353512
|
1
|
0
|
0
|
|
17
|
27
|
Actr
|
Erk
|
-0.753276971381174
|
1908.4536017862
|
17
|
147.847867765778
|
1
|
0
|
0
|
|
18
|
6
|
Activin
|
Erk
|
-0.753278094719914
|
1908.4536018017
|
17
|
147.847867750287
|
1
|
0
|
0
|
|
19
|
384
|
Smad2
|
Erk
|
-2.29713833529869
|
1908.45360180763
|
17
|
147.847867744347
|
1
|
0
|
0
|
|
20
|
34
|
Actr
|
Mek
|
-0.179930950861247
|
1930.52896343579
|
17
|
125.772506116197
|
1
|
0
|
0
|
Link_Selection
Init
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
178
|
Gsk3
|
Igfr
|
3.13276929030024
|
1280.86163056012
|
18
|
775.44
|
2
|
0
|
0
|
Gsk3_Igfr
|
2056.30163056012
|
37.71
|
|
2
|
171
|
Gsk3
|
Akt
|
2.00744510484014
|
1288.7198924196
|
18
|
767.582
|
2
|
0
|
0
|
Gsk3_Akt
|
2056.3018924196
|
37.33
|
|
3
|
183
|
Gsk3
|
Pi3k
|
28.3512885413349
|
1289.13235441924
|
18
|
767.169
|
2
|
0
|
0
|
Gsk3_Pi3k
|
2056.30135441924
|
37.31
|
|
4
|
176
|
Gsk3
|
Fgfr
|
0.191531853873651
|
1372.05906797687
|
18
|
684.242
|
2
|
0
|
0
|
Gsk3_Fgfr
|
2056.30106797687
|
33.28
|
|
5
|
220
|
Jak
|
Igfr
|
0.0748374592692973
|
1503.11324675228
|
17
|
553.188
|
1
|
0
|
0
|
Jak_Igfr
|
2056.30124675228
|
26.9
|
|
6
|
218
|
Jak
|
Fgfr
|
0.0226288712947294
|
1515.31854402861
|
17
|
540.983
|
1
|
0
|
0
|
Jak_Fgfr
|
2056.30154402861
|
26.31
|
|
7
|
225
|
Jak
|
Pi3k
|
0.694735352806384
|
1519.02257775189
|
17
|
537.279
|
1
|
0
|
0
|
Jak_Pi3k
|
2056.30157775189
|
26.13
|
|
8
|
213
|
Jak
|
Akt
|
0.0402569717690179
|
1523.34265168778
|
17
|
532.959
|
1
|
0
|
0
|
Jak_Akt
|
2056.30165168778
|
25.92
|
|
9
|
92
|
Bmp4r
|
Fgfr
|
10.0076490483583
|
1854.77447563085
|
18
|
201.527
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
2056.30147563085
|
9.8
|
|
10
|
29
|
Actr
|
Fgfr
|
-0.792491707221983
|
1894.64741116818
|
17
|
161.654
|
1
|
0
|
0
|
Actr_Fgfr
|
2056.30141116818
|
7.86
|
|
11
|
27
|
Actr
|
Erk
|
-0.753276971381174
|
1908.4536017862
|
17
|
147.848
|
1
|
0
|
0
|
Actr_Erk
|
2056.3016017862
|
7.19
|
|
12
|
34
|
Actr
|
Mek
|
-0.179930950861247
|
1930.52896343579
|
17
|
125.773
|
1
|
0
|
0
|
Actr_Mek
|
2056.30196343579
|
6.12
|
|
13
|
37
|
Actr
|
Raf
|
-0.179930950861247
|
1930.52896343579
|
17
|
125.773
|
1
|
0
|
0
|
Actr_Raf
|
2056.30196343579
|
6.12
|
|
14
|
38
|
Actr
|
Ras
|
-0.179930950861247
|
1930.52896343579
|
17
|
125.773
|
1
|
0
|
0
|
Actr_Ras
|
2056.30196343579
|
6.12
|
|
15
|
90
|
Bmp4r
|
Erk
|
99.9999999993412
|
1945.00798104584
|
18
|
111.293
|
2
|
0
|
0
|
Bmp4r_Erk
|
2056.30098104584
|
5.41
|
|
16
|
94
|
Bmp4r
|
Igfr
|
0.20475439313697
|
1946.079716964
|
18
|
110.222
|
2
|
0
|
0
|
Bmp4r_Igfr
|
2056.301716964
|
5.36
|
|
17
|
241
|
Lifr
|
Igfr
|
-6.66113854683641
|
1951.98475334376
|
17
|
104.317
|
1
|
0
|
0
|
Lifr_Igfr
|
2056.30175334376
|
5.07
|
|
18
|
99
|
Bmp4r
|
Pi3k
|
0.0995819569490456
|
1952.17922246552
|
18
|
104.122
|
2
|
0
|
0
|
Bmp4r_Pi3k
|
2056.30122246552
|
5.06
|
|
19
|
87
|
Bmp4r
|
Akt
|
0.100843870146643
|
1957.94804467494
|
18
|
98.353
|
2
|
0
|
0
|
Bmp4r_Akt
|
2056.30104467494
|
4.78
|
|
20
|
246
|
Lifr
|
Pi3k
|
-7.91739389357748
|
1962.46600542378
|
17
|
93.835
|
1
|
0
|
0
|
Lifr_Pi3k
|
2056.30100542378
|
4.56
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
218
|
Jak
|
Fgfr
|
20.9981411575185
|
1087.34331547367
|
17
|
516.38
|
1
|
0
|
0
|
Jak_Fgfr
|
1603.72331547367
|
32.2
|
|
2
|
216
|
Jak
|
Erk
|
0.694604484418286
|
1259.70107124254
|
17
|
344.022
|
1
|
0
|
0
|
Jak_Erk
|
1603.72307124254
|
21.45
|
|
3
|
223
|
Jak
|
Mek
|
0.153512756290258
|
1274.917666653
|
17
|
328.806
|
1
|
0
|
0
|
Jak_Mek
|
1603.723666653
|
20.5
|
|
4
|
226
|
Jak
|
Raf
|
0.153512756290258
|
1274.917666653
|
17
|
328.806
|
1
|
0
|
0
|
Jak_Raf
|
1603.723666653
|
20.5
|
|
5
|
227
|
Jak
|
Ras
|
0.153512756290258
|
1274.917666653
|
17
|
328.806
|
1
|
0
|
0
|
Jak_Ras
|
1603.723666653
|
20.5
|
|
6
|
239
|
Lifr
|
Fgfr
|
-33.3140786101118
|
1284.20827336381
|
17
|
319.515
|
1
|
0
|
0
|
Lifr_Fgfr
|
1603.72327336381
|
19.92
|
|
7
|
237
|
Lifr
|
Erk
|
-1.0966404370305
|
1307.81404084614
|
17
|
295.909
|
1
|
0
|
0
|
Lifr_Erk
|
1603.72304084614
|
18.45
|
|
8
|
244
|
Lifr
|
Mek
|
-0.239871665422455
|
1311.0867808548
|
17
|
292.637
|
1
|
0
|
0
|
Lifr_Mek
|
1603.7237808548
|
18.25
|
|
9
|
247
|
Lifr
|
Raf
|
-0.239871665422455
|
1311.0867808548
|
17
|
292.637
|
1
|
0
|
0
|
Lifr_Raf
|
1603.7237808548
|
18.25
|
|
10
|
248
|
Lifr
|
Ras
|
-0.239871665422455
|
1311.0867808548
|
17
|
292.637
|
1
|
0
|
0
|
Lifr_Ras
|
1603.7237808548
|
18.25
|
|
11
|
220
|
Jak
|
Igfr
|
0.445029457748117
|
1339.66671374988
|
17
|
264.057
|
1
|
0
|
0
|
Jak_Igfr
|
1603.72371374988
|
16.47
|
|
12
|
225
|
Jak
|
Pi3k
|
9.0879659480259
|
1343.76983211563
|
17
|
259.954
|
1
|
0
|
0
|
Jak_Pi3k
|
1603.72383211563
|
16.21
|
|
13
|
213
|
Jak
|
Akt
|
0.100343803909175
|
1355.5616631844
|
17
|
248.162
|
1
|
0
|
0
|
Jak_Akt
|
1603.7236631844
|
15.47
|
|
14
|
118
|
Erk
|
Mek
|
-0.964630011672275
|
1360.97895223964
|
17
|
242.744
|
1
|
0
|
0
|
Erk_Mek
|
1603.72295223964
|
15.14
|
|
15
|
121
|
Erk
|
Raf
|
-0.964630011672275
|
1360.97895223964
|
17
|
242.744
|
1
|
0
|
0
|
Erk_Raf
|
1603.72295223964
|
15.14
|
|
16
|
122
|
Erk
|
Ras
|
-0.964630011672275
|
1360.97895223964
|
17
|
242.744
|
1
|
0
|
0
|
Erk_Ras
|
1603.72295223964
|
15.14
|
|
17
|
269
|
Mek
|
Ras
|
-3.76437266234742
|
1360.97895224194
|
17
|
242.744
|
1
|
0
|
0
|
Mek_Ras
|
1603.72295224194
|
15.14
|
|
18
|
268
|
Mek
|
Raf
|
-3.76437244203321
|
1360.97895224244
|
17
|
242.744
|
1
|
0
|
0
|
Mek_Raf
|
1603.72295224244
|
15.14
|
|
19
|
219
|
Jak
|
Gsk3
|
0.309068970610719
|
1379.30411368594
|
17
|
224.419
|
1
|
0
|
0
|
Jak_Gsk3
|
1603.72311368594
|
13.99
|
|
20
|
92
|
Bmp4r
|
Fgfr
|
0.242164443044572
|
1416.66260949817
|
18
|
187.061
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
1603.72360949817
|
11.66
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
6
|
Jak_Fgfr
|
540.983
|
0
|
26.31
|
516.38
|
0
|
32.2
|
1057.363
|
58.51
|
|
1
|
Gsk3_Igfr
|
775.44
|
0
|
37.71
|
135.742
|
0
|
8.46
|
911.182
|
46.17
|
|
3
|
Gsk3_Pi3k
|
767.169
|
0
|
37.31
|
132.948
|
0
|
8.29
|
900.117
|
45.6
|
|
2
|
Gsk3_Akt
|
767.582
|
0
|
37.33
|
129.312
|
0
|
8.06
|
896.894
|
45.39
|
|
5
|
Jak_Igfr
|
553.188
|
0
|
26.9
|
264.057
|
0
|
16.47
|
817.245
|
43.37
|
|
7
|
Jak_Pi3k
|
537.279
|
0
|
26.13
|
259.954
|
0
|
16.21
|
797.233
|
42.34
|
|
4
|
Gsk3_Fgfr
|
684.242
|
0
|
33.28
|
136.041
|
0
|
8.48
|
820.283
|
41.76
|
|
8
|
Jak_Akt
|
532.959
|
0
|
25.92
|
248.162
|
0
|
15.47
|
781.121
|
41.39
|
|
28
|
Jak_Erk
|
83.477
|
0
|
4.06
|
344.022
|
0
|
21.45
|
427.499
|
25.51
|
|
23
|
Lifr_Fgfr
|
89.61
|
0
|
4.36
|
319.515
|
0
|
19.92
|
409.125
|
24.28
|
|
29
|
Jak_Mek
|
67.087
|
0
|
3.26
|
328.806
|
0
|
20.5
|
395.893
|
23.76
|
|
30
|
Jak_Raf
|
67.087
|
0
|
3.26
|
328.806
|
0
|
20.5
|
395.893
|
23.76
|
|
31
|
Jak_Ras
|
67.087
|
0
|
3.26
|
328.806
|
0
|
20.5
|
395.893
|
23.76
|
|
9
|
Bmp4r_Fgfr
|
201.527
|
0
|
9.8
|
187.061
|
0
|
11.66
|
388.588
|
21.46
|
|
10
|
Actr_Fgfr
|
161.654
|
0
|
7.86
|
184.891
|
0
|
11.53
|
346.545
|
19.39
|
|
11
|
Actr_Erk
|
147.848
|
0
|
7.19
|
159.145
|
0
|
9.92
|
306.993
|
17.11
|
|
38
|
Erk_Mek
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
|
39
|
Erk_Raf
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
|
40
|
Erk_Ras
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
|
41
|
Mek_Raf
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
LA1
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
178
|
Gsk3
|
Igfr
|
3.68714417419255
|
975.309714366926
|
19
|
539.692
|
2
|
0
|
0
|
Gsk3_Igfr
|
1515.00171436693
|
35.62
|
|
2
|
171
|
Gsk3
|
Akt
|
1.68295194837866
|
980.754743189037
|
19
|
534.247
|
2
|
0
|
0
|
Gsk3_Akt
|
1515.00174318904
|
35.26
|
|
3
|
183
|
Gsk3
|
Pi3k
|
0.947852504056036
|
981.104896871733
|
19
|
533.897
|
2
|
0
|
0
|
Gsk3_Pi3k
|
1515.00189687173
|
35.24
|
|
4
|
176
|
Gsk3
|
Fgfr
|
0.0366262460386825
|
1042.99093581945
|
19
|
472.011
|
2
|
0
|
0
|
Gsk3_Fgfr
|
1515.00193581945
|
31.16
|
|
5
|
179
|
Gsk3
|
Jak
|
3.49480135093296
|
1186.00515889389
|
19
|
328.997
|
2
|
0
|
0
|
Gsk3_Jak
|
1515.00215889389
|
21.72
|
|
6
|
180
|
Gsk3
|
Lifr
|
3.49479944763653
|
1186.0051589303
|
19
|
328.997
|
2
|
0
|
0
|
Gsk3_Lifr
|
1515.0021589303
|
21.72
|
|
7
|
92
|
Bmp4r
|
Fgfr
|
0.137266584770296
|
1379.293214048
|
19
|
135.709
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
1515.002214048
|
8.96
|
|
8
|
95
|
Bmp4r
|
Jak
|
10.0003396735026
|
1405.40002955712
|
19
|
109.602
|
2
|
0
|
0
|
Bmp4r_Jak
|
1515.00202955712
|
7.23
|
|
9
|
96
|
Bmp4r
|
Lifr
|
1356.62829643212
|
1405.40002977268
|
19
|
109.602
|
2
|
0
|
0
|
Bmp4r_Lifr
|
1515.00202977268
|
7.23
|
|
10
|
90
|
Bmp4r
|
Erk
|
0.0999722355484721
|
1409.88137305731
|
19
|
105.121
|
2
|
0
|
0
|
Bmp4r_Erk
|
1515.00237305731
|
6.94
|
|
11
|
27
|
Actr
|
Erk
|
-0.615067412260236
|
1431.05413348414
|
18
|
83.948
|
1
|
0
|
0
|
Actr_Erk
|
1515.00213348414
|
5.54
|
|
12
|
97
|
Bmp4r
|
Mek
|
0.0949591304987643
|
1432.52845600976
|
19
|
82.474
|
2
|
0
|
0
|
Bmp4r_Mek
|
1515.00245600976
|
5.44
|
|
13
|
100
|
Bmp4r
|
Raf
|
0.0949591304987643
|
1432.52845600976
|
19
|
82.474
|
2
|
0
|
0
|
Bmp4r_Raf
|
1515.00245600976
|
5.44
|
|
14
|
101
|
Bmp4r
|
Ras
|
0.0949591304987643
|
1432.52845600976
|
19
|
82.474
|
2
|
0
|
0
|
Bmp4r_Ras
|
1515.00245600976
|
5.44
|
|
15
|
220
|
Jak
|
Igfr
|
0.376191899434823
|
1435.74303261976
|
18
|
79.259
|
1
|
0
|
0
|
Jak_Igfr
|
1515.00203261976
|
5.23
|
|
16
|
29
|
Actr
|
Fgfr
|
-0.183061257182024
|
1436.60116940374
|
18
|
78.401
|
1
|
0
|
0
|
Actr_Fgfr
|
1515.00216940374
|
5.17
|
|
17
|
262
|
Mek
|
Igfr
|
82.9732190722882
|
1443.43774629775
|
18
|
71.564
|
1
|
0
|
0
|
Mek_Igfr
|
1515.00174629775
|
4.72
|
|
18
|
115
|
Erk
|
Igfr
|
4.99462403419405
|
1443.43774630305
|
18
|
71.564
|
1
|
0
|
0
|
Erk_Igfr
|
1515.00174630305
|
4.72
|
|
19
|
34
|
Actr
|
Mek
|
-0.138840203753819
|
1447.09755409619
|
18
|
67.904
|
1
|
2.22044604925031e-16
|
0
|
Actr_Mek
|
1515.00155409619
|
4.48
|
|
20
|
37
|
Actr
|
Raf
|
-0.138840203753819
|
1447.09755409619
|
18
|
67.904
|
1
|
2.22044604925031e-16
|
0
|
Actr_Raf
|
1515.00155409619
|
4.48
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
268
|
Mek
|
Raf
|
-5.83511695507381
|
815.631614262065
|
18
|
247.924
|
1
|
0
|
0
|
Mek_Raf
|
1063.55561426207
|
23.31
|
|
2
|
121
|
Erk
|
Raf
|
-1.31339551691328
|
815.631614274121
|
18
|
247.924
|
1
|
0
|
0
|
Erk_Raf
|
1063.55561427412
|
23.31
|
|
3
|
118
|
Erk
|
Mek
|
-1.3133961412702
|
815.631614274281
|
18
|
247.924
|
1
|
0
|
0
|
Erk_Mek
|
1063.55561427428
|
23.31
|
|
4
|
122
|
Erk
|
Ras
|
-1.3133961412702
|
815.631614274281
|
18
|
247.924
|
1
|
0
|
0
|
Erk_Ras
|
1063.55561427428
|
23.31
|
|
5
|
269
|
Mek
|
Ras
|
-5.8351805500926
|
815.631614330806
|
18
|
247.924
|
1
|
0
|
0
|
Mek_Ras
|
1063.55561433081
|
23.31
|
|
6
|
92
|
Bmp4r
|
Fgfr
|
99.9999996143922
|
953.75111984009
|
19
|
109.805
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
1063.55611984009
|
10.32
|
|
7
|
29
|
Actr
|
Fgfr
|
-0.107642013460403
|
960.885942674455
|
18
|
102.67
|
1
|
0
|
0
|
Actr_Fgfr
|
1063.55594267446
|
9.65
|
|
8
|
97
|
Bmp4r
|
Mek
|
99.999999999432
|
962.159238790498
|
19
|
101.397
|
2
|
0
|
0
|
Bmp4r_Mek
|
1063.5562387905
|
9.53
|
|
9
|
100
|
Bmp4r
|
Raf
|
99.999999999432
|
962.159238790498
|
19
|
101.397
|
2
|
0
|
0
|
Bmp4r_Raf
|
1063.5562387905
|
9.53
|
|
10
|
101
|
Bmp4r
|
Ras
|
99.999999999432
|
962.159238790498
|
19
|
101.397
|
2
|
0
|
0
|
Bmp4r_Ras
|
1063.5562387905
|
9.53
|
|
11
|
179
|
Gsk3
|
Jak
|
0.10986058964512
|
962.880760078898
|
19
|
100.675
|
2
|
0
|
0
|
Gsk3_Jak
|
1063.5557600789
|
9.47
|
|
12
|
180
|
Gsk3
|
Lifr
|
0.10986080686882
|
962.880760096549
|
19
|
100.675
|
2
|
0
|
0
|
Gsk3_Lifr
|
1063.55576009655
|
9.47
|
|
13
|
90
|
Bmp4r
|
Erk
|
0.101155680085491
|
964.022331185148
|
19
|
99.534
|
2
|
0
|
0
|
Bmp4r_Erk
|
1063.55633118515
|
9.36
|
|
14
|
27
|
Actr
|
Erk
|
-0.76329033426765
|
964.487925925433
|
18
|
99.068
|
1
|
0
|
0
|
Actr_Erk
|
1063.55592592543
|
9.31
|
|
15
|
34
|
Actr
|
Mek
|
-0.150168153779694
|
966.972716199464
|
18
|
96.583
|
1
|
0
|
0
|
Actr_Mek
|
1063.55571619946
|
9.08
|
|
16
|
37
|
Actr
|
Raf
|
-0.150168153779694
|
966.972716199464
|
18
|
96.583
|
1
|
0
|
0
|
Actr_Raf
|
1063.55571619946
|
9.08
|
|
17
|
38
|
Actr
|
Ras
|
-0.150168153779694
|
966.972716199464
|
18
|
96.583
|
1
|
0
|
0
|
Actr_Ras
|
1063.55571619946
|
9.08
|
|
18
|
178
|
Gsk3
|
Igfr
|
1.30156682482258
|
970.63466881692
|
19
|
92.921
|
2
|
0
|
0
|
Gsk3_Igfr
|
1063.55566881692
|
8.74
|
|
19
|
171
|
Gsk3
|
Akt
|
0.398693555098299
|
975.230119492535
|
19
|
88.326
|
2
|
0
|
0
|
Gsk3_Akt
|
1063.55611949253
|
8.3
|
|
20
|
183
|
Gsk3
|
Pi3k
|
39.0065014570521
|
975.290708474135
|
19
|
88.265
|
2
|
0
|
0
|
Gsk3_Pi3k
|
1063.55570847414
|
8.3
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Gsk3_Igfr
|
539.692
|
0
|
35.62
|
92.921
|
0
|
8.74
|
632.613
|
44.36
|
|
2
|
Gsk3_Akt
|
534.247
|
0
|
35.26
|
88.326
|
0
|
8.3
|
622.573
|
43.56
|
|
3
|
Gsk3_Pi3k
|
533.897
|
0
|
35.24
|
88.265
|
0
|
8.3
|
622.162
|
43.54
|
|
4
|
Gsk3_Fgfr
|
472.011
|
0
|
31.16
|
62.94
|
0
|
5.92
|
534.951
|
37.08
|
|
5
|
Gsk3_Jak
|
328.997
|
0
|
21.72
|
100.675
|
0
|
9.47
|
429.672
|
31.19
|
|
6
|
Gsk3_Lifr
|
328.997
|
0
|
21.72
|
100.675
|
0
|
9.47
|
429.672
|
31.19
|
|
29
|
Mek_Raf
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
30
|
Mek_Ras
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
31
|
Erk_Mek
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
32
|
Erk_Raf
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
33
|
Erk_Ras
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
7
|
Bmp4r_Fgfr
|
135.709
|
0
|
8.96
|
109.805
|
0
|
10.32
|
245.514
|
19.28
|
|
10
|
Bmp4r_Erk
|
105.121
|
0
|
6.94
|
99.534
|
0
|
9.36
|
204.655
|
16.3
|
|
8
|
Bmp4r_Jak
|
109.602
|
0
|
7.23
|
85.461
|
0
|
8.04
|
195.063
|
15.27
|
|
9
|
Bmp4r_Lifr
|
109.602
|
0
|
7.23
|
85.461
|
0
|
8.04
|
195.063
|
15.27
|
|
12
|
Bmp4r_Mek
|
82.474
|
0
|
5.44
|
101.397
|
0
|
9.53
|
183.871
|
14.97
|
|
13
|
Bmp4r_Raf
|
82.474
|
0
|
5.44
|
101.397
|
0
|
9.53
|
183.871
|
14.97
|
|
14
|
Bmp4r_Ras
|
82.474
|
0
|
5.44
|
101.397
|
0
|
9.53
|
183.871
|
14.97
|
|
11
|
Actr_Erk
|
83.948
|
0
|
5.54
|
99.068
|
0
|
9.31
|
183.016
|
14.85
|
|
16
|
Actr_Fgfr
|
78.401
|
0
|
5.17
|
102.67
|
0
|
9.65
|
181.071
|
14.82
|
LA2
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
92
|
Bmp4r
|
Fgfr
|
100.000000000035
|
840.631122580894
|
21
|
130.329
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
970.960122580894
|
13.42
|
|
2
|
90
|
Bmp4r
|
Erk
|
99.9999999987995
|
866.335382828316
|
21
|
104.625
|
2
|
0
|
0
|
Bmp4r_Erk
|
970.960382828316
|
10.78
|
|
3
|
96
|
Bmp4r
|
Lifr
|
2.35528494640207
|
879.021008830448
|
21
|
91.939
|
2
|
0
|
0
|
Bmp4r_Lifr
|
970.960008830448
|
9.47
|
|
4
|
95
|
Bmp4r
|
Jak
|
100.000000009116
|
880.118790070241
|
21
|
90.841
|
2
|
0
|
0
|
Bmp4r_Jak
|
970.959790070241
|
9.36
|
|
5
|
27
|
Actr
|
Erk
|
-0.609450484425741
|
886.55941310913
|
20
|
84.401
|
1
|
0
|
0
|
Actr_Erk
|
970.96041310913
|
8.69
|
|
6
|
97
|
Bmp4r
|
Mek
|
99.9999999997936
|
890.523505991998
|
21
|
80.437
|
2
|
0
|
0
|
Bmp4r_Mek
|
970.960505991998
|
8.28
|
|
7
|
100
|
Bmp4r
|
Raf
|
99.9999999997936
|
890.523505991998
|
21
|
80.437
|
2
|
0
|
0
|
Bmp4r_Raf
|
970.960505991998
|
8.28
|
|
8
|
101
|
Bmp4r
|
Ras
|
99.9999999997936
|
890.523505991998
|
21
|
80.437
|
2
|
0
|
0
|
Bmp4r_Ras
|
970.960505991998
|
8.28
|
|
9
|
213
|
Jak
|
Akt
|
0.000419253601447264
|
901.164708669303
|
20
|
69.795
|
1
|
1.11022302462516e-16
|
0
|
Jak_Akt
|
970.959708669303
|
7.19
|
|
10
|
219
|
Jak
|
Gsk3
|
0.00020314887762156
|
901.186098428986
|
20
|
69.774
|
1
|
1.11022302462516e-16
|
0
|
Jak_Gsk3
|
970.960098428986
|
7.19
|
|
11
|
220
|
Jak
|
Igfr
|
0.000172377512952438
|
901.360783509842
|
20
|
69.599
|
1
|
1.11022302462516e-16
|
0
|
Jak_Igfr
|
970.959783509842
|
7.17
|
|
12
|
225
|
Jak
|
Pi3k
|
0.000127340116679159
|
901.430299565741
|
20
|
69.53
|
1
|
1.11022302462516e-16
|
0
|
Jak_Pi3k
|
970.960299565741
|
7.16
|
|
13
|
223
|
Jak
|
Mek
|
-0.122906797913527
|
903.921487153192
|
20
|
67.039
|
1
|
2.22044604925031e-16
|
0
|
Jak_Mek
|
970.960487153192
|
6.9
|
|
14
|
227
|
Jak
|
Ras
|
-0.122906799513724
|
903.921487517344
|
20
|
67.039
|
1
|
2.22044604925031e-16
|
0
|
Jak_Ras
|
970.960487517344
|
6.9
|
|
15
|
226
|
Jak
|
Raf
|
-0.122906804680376
|
903.921489136838
|
20
|
67.039
|
1
|
2.22044604925031e-16
|
0
|
Jak_Raf
|
970.960489136838
|
6.9
|
|
16
|
34
|
Actr
|
Mek
|
-0.145787225705084
|
904.346765345538
|
20
|
66.613
|
1
|
3.33066907387547e-16
|
0
|
Actr_Mek
|
970.959765345538
|
6.86
|
|
17
|
37
|
Actr
|
Raf
|
-0.145787225705084
|
904.346765345538
|
20
|
66.613
|
1
|
3.33066907387547e-16
|
0
|
Actr_Raf
|
970.959765345538
|
6.86
|
|
18
|
38
|
Actr
|
Ras
|
-0.145787225705084
|
904.346765345538
|
20
|
66.613
|
1
|
3.33066907387547e-16
|
0
|
Actr_Ras
|
970.959765345538
|
6.86
|
|
19
|
29
|
Actr
|
Fgfr
|
-0.0978734911570697
|
916.930539295931
|
20
|
54.03
|
1
|
1.97508676080815e-13
|
0
|
Actr_Fgfr
|
970.960539295931
|
5.56
|
|
20
|
103
|
Bmp4r
|
Smad2
|
1.00073497067606
|
924.909915433487
|
21
|
46.05
|
2
|
1.00074282194385e-10
|
0
|
Bmp4r_Smad2
|
970.959915433487
|
4.74
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
268
|
Mek
|
Raf
|
-5.68048487785159
|
720.150028354858
|
20
|
250.48
|
1
|
0
|
0
|
Mek_Raf
|
970.630028354858
|
25.81
|
|
2
|
269
|
Mek
|
Ras
|
-5.68025951188421
|
720.15170496036
|
20
|
250.478
|
1
|
0
|
0
|
Mek_Ras
|
970.62970496036
|
25.81
|
|
3
|
118
|
Erk
|
Mek
|
-1.30965243655132
|
720.409297973402
|
20
|
250.221
|
1
|
0
|
0
|
Erk_Mek
|
970.630297973402
|
25.78
|
|
4
|
122
|
Erk
|
Ras
|
-1.30965243655132
|
720.409297973402
|
20
|
250.221
|
1
|
0
|
0
|
Erk_Ras
|
970.630297973402
|
25.78
|
|
5
|
121
|
Erk
|
Raf
|
-1.30979470816556
|
720.725667118639
|
20
|
249.904
|
1
|
0
|
0
|
Erk_Raf
|
970.629667118639
|
25.75
|
|
6
|
92
|
Bmp4r
|
Fgfr
|
9.99999993103222
|
867.433820816206
|
21
|
103.196
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
970.629820816206
|
10.63
|
|
7
|
97
|
Bmp4r
|
Mek
|
9.99999867158272
|
869.583647337226
|
21
|
101.046
|
2
|
0
|
0
|
Bmp4r_Mek
|
970.629647337226
|
10.41
|
|
8
|
100
|
Bmp4r
|
Raf
|
9.99999867158272
|
869.583647337226
|
21
|
101.046
|
2
|
0
|
0
|
Bmp4r_Raf
|
970.629647337226
|
10.41
|
|
9
|
101
|
Bmp4r
|
Ras
|
9.99999867158272
|
869.583647337226
|
21
|
101.046
|
2
|
0
|
0
|
Bmp4r_Ras
|
970.629647337226
|
10.41
|
|
10
|
90
|
Bmp4r
|
Erk
|
1.05449863435004
|
871.564012826834
|
21
|
99.066
|
2
|
0
|
0
|
Bmp4r_Erk
|
970.630012826834
|
10.21
|
|
11
|
27
|
Actr
|
Erk
|
-0.758744726333682
|
872.346764632357
|
20
|
98.283
|
1
|
0
|
0
|
Actr_Erk
|
970.629764632357
|
10.13
|
|
12
|
34
|
Actr
|
Mek
|
-0.158377406543334
|
875.836265640398
|
20
|
94.794
|
1
|
0
|
0
|
Actr_Mek
|
970.630265640398
|
9.77
|
|
13
|
37
|
Actr
|
Raf
|
-0.158377406543334
|
875.836265640398
|
20
|
94.794
|
1
|
0
|
0
|
Actr_Raf
|
970.630265640398
|
9.77
|
|
14
|
38
|
Actr
|
Ras
|
-0.158377406543334
|
875.836265640398
|
20
|
94.794
|
1
|
0
|
0
|
Actr_Ras
|
970.630265640398
|
9.77
|
|
15
|
29
|
Actr
|
Fgfr
|
-0.111973741541661
|
877.0356994209
|
20
|
93.594
|
1
|
0
|
0
|
Actr_Fgfr
|
970.6296994209
|
9.64
|
|
16
|
103
|
Bmp4r
|
Smad2
|
100.000000012164
|
889.285467486331
|
21
|
81.345
|
2
|
0
|
0
|
Bmp4r_Smad2
|
970.630467486331
|
8.38
|
|
17
|
86
|
Bmp4r
|
Actr
|
100.000000012164
|
889.285467498141
|
21
|
81.345
|
2
|
0
|
0
|
Bmp4r_Actr
|
970.630467498141
|
8.38
|
|
18
|
95
|
Bmp4r
|
Jak
|
99.9999999981261
|
892.690518521311
|
21
|
77.94
|
2
|
0
|
0
|
Bmp4r_Jak
|
970.630518521311
|
8.03
|
|
19
|
96
|
Bmp4r
|
Lifr
|
145.337968119767
|
893.256092412717
|
21
|
77.374
|
2
|
0
|
0
|
Bmp4r_Lifr
|
970.630092412717
|
7.97
|
|
20
|
219
|
Jak
|
Gsk3
|
0.0925560747530236
|
915.44901922933
|
20
|
55.181
|
1
|
1.0991207943789e-13
|
0
|
Jak_Gsk3
|
970.63001922933
|
5.69
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
22
|
Erk_Mek
|
38.52
|
0
|
3.97
|
250.221
|
0
|
25.78
|
288.741
|
29.75
|
|
24
|
Erk_Ras
|
38.52
|
0
|
3.97
|
250.221
|
0
|
25.78
|
288.741
|
29.75
|
|
23
|
Erk_Raf
|
38.52
|
0
|
3.97
|
249.904
|
0
|
25.75
|
288.424
|
29.72
|
|
25
|
Mek_Raf
|
37.958
|
0
|
3.91
|
250.48
|
0
|
25.81
|
288.438
|
29.72
|
|
26
|
Mek_Ras
|
37.958
|
0
|
3.91
|
250.478
|
0
|
25.81
|
288.436
|
29.72
|
|
1
|
Bmp4r_Fgfr
|
130.329
|
0
|
13.42
|
103.196
|
0
|
10.63
|
233.525
|
24.05
|
|
2
|
Bmp4r_Erk
|
104.625
|
0
|
10.78
|
99.066
|
0
|
10.21
|
203.691
|
20.99
|
|
5
|
Actr_Erk
|
84.401
|
0
|
8.69
|
98.283
|
0
|
10.13
|
182.684
|
18.82
|
|
6
|
Bmp4r_Mek
|
80.437
|
0
|
8.28
|
101.046
|
0
|
10.41
|
181.483
|
18.69
|
|
7
|
Bmp4r_Raf
|
80.437
|
0
|
8.28
|
101.046
|
0
|
10.41
|
181.483
|
18.69
|
|
8
|
Bmp4r_Ras
|
80.437
|
0
|
8.28
|
101.046
|
0
|
10.41
|
181.483
|
18.69
|
|
3
|
Bmp4r_Lifr
|
91.939
|
0
|
9.47
|
77.374
|
0
|
7.97
|
169.313
|
17.44
|
|
4
|
Bmp4r_Jak
|
90.841
|
0
|
9.36
|
77.94
|
0
|
8.03
|
168.781
|
17.39
|
|
16
|
Actr_Mek
|
66.613
|
0
|
6.86
|
94.794
|
0
|
9.77
|
161.407
|
16.63
|
|
17
|
Actr_Raf
|
66.613
|
0
|
6.86
|
94.794
|
0
|
9.77
|
161.407
|
16.63
|
|
18
|
Actr_Ras
|
66.613
|
0
|
6.86
|
94.794
|
0
|
9.77
|
161.407
|
16.63
|
|
19
|
Actr_Fgfr
|
54.03
|
0
|
5.56
|
93.594
|
0
|
9.64
|
147.624
|
15.2
|
|
20
|
Bmp4r_Smad2
|
46.05
|
0
|
4.74
|
81.345
|
0
|
8.38
|
127.395
|
13.12
|
|
21
|
Bmp4r_Actr
|
46.05
|
0
|
4.74
|
81.345
|
0
|
8.38
|
127.395
|
13.12
|
|
10
|
Jak_Gsk3
|
69.774
|
0
|
7.19
|
55.181
|
0
|
5.69
|
124.955
|
12.88
|
LA3
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
92
|
Bmp4r
|
Fgfr
|
9.99999989258064
|
800.489508527619
|
22
|
131.646
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
932.135508527619
|
14.12
|
|
2
|
90
|
Bmp4r
|
Erk
|
10.0000061725532
|
824.455100300836
|
22
|
107.681
|
2
|
0
|
0
|
Bmp4r_Erk
|
932.136100300836
|
11.55
|
|
3
|
96
|
Bmp4r
|
Lifr
|
2.44333632158931
|
839.394572423977
|
22
|
92.741
|
2
|
0
|
0
|
Bmp4r_Lifr
|
932.135572423977
|
9.95
|
|
4
|
95
|
Bmp4r
|
Jak
|
100.000000017537
|
840.213964306029
|
22
|
91.922
|
2
|
0
|
0
|
Bmp4r_Jak
|
932.135964306029
|
9.86
|
|
5
|
27
|
Actr
|
Erk
|
-0.787586097304015
|
845.537051106361
|
21
|
86.599
|
1
|
0
|
0
|
Actr_Erk
|
932.136051106361
|
9.29
|
|
6
|
97
|
Bmp4r
|
Mek
|
99.9999999997231
|
849.25343702957
|
22
|
82.883
|
2
|
0
|
0
|
Bmp4r_Mek
|
932.13643702957
|
8.89
|
|
7
|
100
|
Bmp4r
|
Raf
|
99.9999999997231
|
849.25343702957
|
22
|
82.883
|
2
|
0
|
0
|
Bmp4r_Raf
|
932.13643702957
|
8.89
|
|
8
|
101
|
Bmp4r
|
Ras
|
99.9999999997231
|
849.25343702957
|
22
|
82.883
|
2
|
0
|
0
|
Bmp4r_Ras
|
932.13643702957
|
8.89
|
|
9
|
34
|
Actr
|
Mek
|
-0.203517862423544
|
862.688904419659
|
21
|
69.447
|
1
|
1.11022302462516e-16
|
0
|
Actr_Mek
|
932.135904419659
|
7.45
|
|
10
|
38
|
Actr
|
Ras
|
-0.203517862423544
|
862.688904419659
|
21
|
69.447
|
1
|
1.11022302462516e-16
|
0
|
Actr_Ras
|
932.135904419659
|
7.45
|
|
11
|
37
|
Actr
|
Raf
|
-0.203517862425133
|
862.68890441968
|
21
|
69.447
|
1
|
1.11022302462516e-16
|
0
|
Actr_Raf
|
932.13590441968
|
7.45
|
|
12
|
213
|
Jak
|
Akt
|
0.000365979200408284
|
863.85572187149
|
21
|
68.28
|
1
|
1.11022302462516e-16
|
0
|
Jak_Akt
|
932.13572187149
|
7.33
|
|
13
|
219
|
Jak
|
Gsk3
|
0.000143726138757871
|
864.1265734424
|
21
|
68.009
|
1
|
1.11022302462516e-16
|
0
|
Jak_Gsk3
|
932.1355734424
|
7.3
|
|
14
|
220
|
Jak
|
Igfr
|
6.99241001437148e-05
|
864.213109296983
|
21
|
67.923
|
1
|
2.22044604925031e-16
|
0
|
Jak_Igfr
|
932.136109296983
|
7.29
|
|
15
|
225
|
Jak
|
Pi3k
|
7.42860206317546e-05
|
864.264538929678
|
21
|
67.871
|
1
|
2.22044604925031e-16
|
0
|
Jak_Pi3k
|
932.135538929678
|
7.28
|
|
16
|
223
|
Jak
|
Mek
|
-0.143447522438166
|
870.016410112819
|
21
|
62.12
|
1
|
3.21964677141295e-15
|
0
|
Jak_Mek
|
932.136410112819
|
6.66
|
|
17
|
227
|
Jak
|
Ras
|
-0.143447485766896
|
870.016430377451
|
21
|
62.12
|
1
|
3.21964677141295e-15
|
0
|
Jak_Ras
|
932.136430377451
|
6.66
|
|
18
|
226
|
Jak
|
Raf
|
-0.143447485164996
|
870.016430652343
|
21
|
62.12
|
1
|
3.21964677141295e-15
|
0
|
Jak_Raf
|
932.136430652343
|
6.66
|
|
19
|
29
|
Actr
|
Fgfr
|
-0.0821446845397702
|
875.91009068482
|
21
|
56.226
|
1
|
6.46149800331841e-14
|
0
|
Actr_Fgfr
|
932.13609068482
|
6.03
|
|
20
|
103
|
Bmp4r
|
Smad2
|
1.00279601120976
|
886.118769499158
|
22
|
46.017
|
2
|
1.01738506508298e-10
|
0
|
Bmp4r_Smad2
|
932.135769499158
|
4.94
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
92
|
Bmp4r
|
Fgfr
|
1.00017504349991
|
611.700315300792
|
22
|
108.36
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
720.060315300792
|
15.05
|
|
2
|
97
|
Bmp4r
|
Mek
|
100.000000039339
|
614.975264101
|
22
|
105.085
|
2
|
0
|
0
|
Bmp4r_Mek
|
720.060264101
|
14.59
|
|
3
|
100
|
Bmp4r
|
Raf
|
100.000000039339
|
614.975264101
|
22
|
105.085
|
2
|
0
|
0
|
Bmp4r_Raf
|
720.060264101
|
14.59
|
|
4
|
101
|
Bmp4r
|
Ras
|
100.000000039339
|
614.975264101
|
22
|
105.085
|
2
|
0
|
0
|
Bmp4r_Ras
|
720.060264101
|
14.59
|
|
5
|
34
|
Actr
|
Mek
|
-1.04471427968771
|
628.215201432379
|
21
|
91.845
|
1
|
0
|
0
|
Actr_Mek
|
720.060201432379
|
12.76
|
|
6
|
38
|
Actr
|
Ras
|
-1.04471427968771
|
628.215201432379
|
21
|
91.845
|
1
|
0
|
0
|
Actr_Ras
|
720.060201432379
|
12.76
|
|
7
|
37
|
Actr
|
Raf
|
-1.04471424940284
|
628.215207421624
|
21
|
91.845
|
1
|
0
|
0
|
Actr_Raf
|
720.060207421624
|
12.76
|
|
8
|
29
|
Actr
|
Fgfr
|
-0.095628702085323
|
628.980258093207
|
21
|
91.08
|
1
|
0
|
0
|
Actr_Fgfr
|
720.060258093207
|
12.65
|
|
9
|
96
|
Bmp4r
|
Lifr
|
1.41042555033286
|
636.525329768387
|
22
|
83.535
|
2
|
0
|
0
|
Bmp4r_Lifr
|
720.060329768387
|
11.6
|
|
10
|
95
|
Bmp4r
|
Jak
|
99.9999999991175
|
637.462042126243
|
22
|
82.598
|
2
|
0
|
0
|
Bmp4r_Jak
|
720.060042126243
|
11.47
|
|
11
|
103
|
Bmp4r
|
Smad2
|
1.00165261367737
|
638.747808236162
|
22
|
81.313
|
2
|
0
|
0
|
Bmp4r_Smad2
|
720.060808236162
|
11.29
|
|
12
|
86
|
Bmp4r
|
Actr
|
1.00165261367736
|
638.747808236176
|
22
|
81.313
|
2
|
0
|
0
|
Bmp4r_Actr
|
720.060808236176
|
11.29
|
|
13
|
219
|
Jak
|
Gsk3
|
0.0957107344795876
|
658.700053830958
|
21
|
61.36
|
1
|
4.77395900588817e-15
|
0
|
Jak_Gsk3
|
720.060053830958
|
8.52
|
|
14
|
225
|
Jak
|
Pi3k
|
0.00762595490442734
|
661.489247286806
|
21
|
58.571
|
1
|
1.96509475358653e-14
|
0
|
Jak_Pi3k
|
720.060247286806
|
8.13
|
|
15
|
220
|
Jak
|
Igfr
|
0.00181429906824424
|
661.52434071194
|
21
|
58.536
|
1
|
1.99840144432528e-14
|
0
|
Jak_Igfr
|
720.06034071194
|
8.13
|
|
16
|
213
|
Jak
|
Akt
|
0.00127129101721937
|
661.611697458647
|
21
|
58.449
|
1
|
2.08721928629529e-14
|
0
|
Jak_Akt
|
720.060697458647
|
8.12
|
|
17
|
223
|
Jak
|
Mek
|
-4.33704546101835
|
662.983925294919
|
21
|
57.077
|
1
|
4.19664303308309e-14
|
0
|
Jak_Mek
|
720.060925294919
|
7.93
|
|
18
|
227
|
Jak
|
Ras
|
-4.19150153451327
|
663.134201717124
|
21
|
56.926
|
1
|
4.52970994047064e-14
|
0
|
Jak_Ras
|
720.060201717124
|
7.91
|
|
19
|
226
|
Jak
|
Raf
|
-3.75971344750539
|
663.82235661755
|
21
|
56.238
|
1
|
6.4170890823334e-14
|
0
|
Jak_Raf
|
720.06035661755
|
7.81
|
|
20
|
32
|
Actr
|
Jak
|
-0.507547608865538
|
670.237936826029
|
21
|
49.822
|
1
|
1.68298708302927e-12
|
0
|
Actr_Jak
|
720.059936826029
|
6.92
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Bmp4r_Fgfr
|
131.646
|
0
|
14.12
|
108.36
|
0
|
15.05
|
240.006
|
29.17
|
|
5
|
Bmp4r_Mek
|
82.883
|
0
|
8.89
|
105.085
|
0
|
14.59
|
187.968
|
23.48
|
|
6
|
Bmp4r_Raf
|
82.883
|
0
|
8.89
|
105.085
|
0
|
14.59
|
187.968
|
23.48
|
|
7
|
Bmp4r_Ras
|
82.883
|
0
|
8.89
|
105.085
|
0
|
14.59
|
187.968
|
23.48
|
|
2
|
Bmp4r_Lifr
|
92.741
|
0
|
9.95
|
83.535
|
0
|
11.6
|
176.276
|
21.55
|
|
3
|
Bmp4r_Jak
|
91.922
|
0
|
9.86
|
82.598
|
0
|
11.47
|
174.52
|
21.33
|
|
8
|
Actr_Mek
|
69.447
|
0
|
7.45
|
91.845
|
0
|
12.76
|
161.292
|
20.21
|
|
9
|
Actr_Ras
|
69.447
|
0
|
7.45
|
91.845
|
0
|
12.76
|
161.292
|
20.21
|
|
10
|
Actr_Raf
|
69.447
|
0
|
7.45
|
91.845
|
0
|
12.76
|
161.292
|
20.21
|
|
18
|
Actr_Fgfr
|
56.226
|
0
|
6.03
|
91.08
|
0
|
12.65
|
147.306
|
18.68
|
|
19
|
Bmp4r_Smad2
|
46.017
|
0
|
4.94
|
81.313
|
0
|
11.29
|
127.33
|
16.23
|
|
20
|
Bmp4r_Actr
|
46.017
|
0
|
4.94
|
81.313
|
0
|
11.29
|
127.33
|
16.23
|
|
12
|
Jak_Gsk3
|
68.009
|
0
|
7.3
|
61.36
|
0
|
8.52
|
129.369
|
15.82
|
|
11
|
Jak_Akt
|
68.28
|
0
|
7.33
|
58.449
|
0
|
8.12
|
126.729
|
15.45
|
|
13
|
Jak_Igfr
|
67.923
|
0
|
7.29
|
58.536
|
0
|
8.13
|
126.459
|
15.42
|
|
14
|
Jak_Pi3k
|
67.871
|
0
|
7.28
|
58.571
|
0
|
8.13
|
126.442
|
15.41
|
|
15
|
Jak_Mek
|
62.12
|
0
|
6.66
|
57.077
|
0
|
7.93
|
119.197
|
14.59
|
|
16
|
Jak_Ras
|
62.12
|
0
|
6.66
|
56.926
|
0
|
7.91
|
119.046
|
14.57
|
|
17
|
Jak_Raf
|
62.12
|
0
|
6.66
|
56.238
|
0
|
7.81
|
118.358
|
14.47
|
|
4
|
Actr_Erk
|
86.599
|
0
|
9.29
|
22.208
|
0.001
|
3.08
|
108.807
|
12.37
|
LA4
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
213
|
Jak
|
Akt
|
0.000498128280588802
|
738.147716191157
|
23
|
60.146
|
1
|
8.77076189453874e-15
|
0
|
Jak_Akt
|
798.293716191157
|
7.53
|
|
2
|
219
|
Jak
|
Gsk3
|
0.000354679603965509
|
738.196248523367
|
23
|
60.097
|
1
|
8.99280649946377e-15
|
0
|
Jak_Gsk3
|
798.293248523367
|
7.53
|
|
3
|
220
|
Jak
|
Igfr
|
0.000105246408657529
|
738.306015155016
|
23
|
59.988
|
1
|
9.54791801177635e-15
|
0
|
Jak_Igfr
|
798.294015155016
|
7.51
|
|
4
|
225
|
Jak
|
Pi3k
|
0.000236714658754552
|
738.350273655003
|
23
|
59.943
|
1
|
9.76996261670138e-15
|
0
|
Jak_Pi3k
|
798.293273655003
|
7.51
|
|
5
|
227
|
Jak
|
Ras
|
-0.166748915696276
|
749.589351842409
|
23
|
48.704
|
1
|
2.97617486211266e-12
|
0
|
Jak_Ras
|
798.293351842409
|
6.1
|
|
6
|
223
|
Jak
|
Mek
|
-0.166748874957404
|
749.589360034352
|
23
|
48.704
|
1
|
2.97617486211266e-12
|
0
|
Jak_Mek
|
798.293360034352
|
6.1
|
|
7
|
226
|
Jak
|
Raf
|
-0.16674885028288
|
749.589365471779
|
23
|
48.704
|
1
|
2.97617486211266e-12
|
0
|
Jak_Raf
|
798.293365471779
|
6.1
|
|
8
|
317
|
Raf
|
Actr
|
0.322276720958421
|
749.59906883644
|
23
|
48.695
|
1
|
2.99094082834017e-12
|
0
|
Raf_Actr
|
798.29406883644
|
6.1
|
|
9
|
355
|
Ras
|
Smad2
|
0.322277616308061
|
749.599075847399
|
23
|
48.695
|
1
|
2.99094082834017e-12
|
0
|
Ras_Smad2
|
798.294075847399
|
6.1
|
|
10
|
334
|
Raf
|
Smad2
|
0.322277669996231
|
749.599076262919
|
23
|
48.695
|
1
|
2.99094082834017e-12
|
0
|
Raf_Smad2
|
798.294076262919
|
6.1
|
|
11
|
338
|
Ras
|
Actr
|
0.322277706849764
|
749.599078178269
|
23
|
48.695
|
1
|
2.99094082834017e-12
|
0
|
Ras_Actr
|
798.294078178269
|
6.1
|
|
12
|
149
|
Fgfr
|
Actr
|
0.323904084271943
|
749.601092995369
|
23
|
48.693
|
1
|
2.99404945280912e-12
|
0
|
Fgfr_Actr
|
798.294092995369
|
6.1
|
|
13
|
166
|
Fgfr
|
Smad2
|
0.32390408433123
|
749.601092995999
|
23
|
48.693
|
1
|
2.99404945280912e-12
|
0
|
Fgfr_Smad2
|
798.294092995999
|
6.1
|
|
14
|
27
|
Actr
|
Erk
|
-0.426069352335274
|
755.91483353031
|
23
|
42.379
|
1
|
7.52017337291022e-11
|
0
|
Actr_Erk
|
798.29383353031
|
5.31
|
|
15
|
86
|
Bmp4r
|
Actr
|
1.03956855887091
|
763.216250381519
|
23
|
35.077
|
1
|
3.16863768556885e-09
|
0
|
Bmp4r_Actr
|
798.293250381519
|
4.39
|
|
16
|
103
|
Bmp4r
|
Smad2
|
1.03956860204103
|
763.216368825825
|
23
|
35.077
|
1
|
3.16883042028593e-09
|
0
|
Bmp4r_Smad2
|
798.293368825825
|
4.39
|
|
17
|
37
|
Actr
|
Raf
|
-0.148141590426734
|
763.534326461282
|
23
|
34.759
|
1
|
3.73095632166809e-09
|
0
|
Actr_Raf
|
798.293326461282
|
4.35
|
|
18
|
38
|
Actr
|
Ras
|
-0.148141590426734
|
763.534326461282
|
23
|
34.759
|
1
|
3.73095632166809e-09
|
0
|
Actr_Ras
|
798.293326461282
|
4.35
|
|
19
|
34
|
Actr
|
Mek
|
-0.148141566067673
|
763.534337183549
|
23
|
34.759
|
1
|
3.73097686079404e-09
|
0
|
Actr_Mek
|
798.293337183549
|
4.35
|
|
20
|
296
|
Pi3k
|
Actr
|
0.267057552327755
|
764.726640414079
|
23
|
33.567
|
1
|
6.88521084590832e-09
|
0
|
Pi3k_Actr
|
798.293640414079
|
4.2
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
86
|
Bmp4r
|
Actr
|
5.86687019434621
|
530.138061090517
|
23
|
81.343
|
1
|
0
|
0
|
Bmp4r_Actr
|
611.481061090517
|
13.3
|
|
2
|
103
|
Bmp4r
|
Smad2
|
5.86688396987027
|
530.138065632416
|
23
|
81.343
|
1
|
0
|
0
|
Bmp4r_Smad2
|
611.481065632416
|
13.3
|
|
3
|
219
|
Jak
|
Gsk3
|
0.0972369985413909
|
547.331781134442
|
23
|
64.149
|
1
|
1.11022302462516e-15
|
0
|
Jak_Gsk3
|
611.480781134442
|
10.49
|
|
4
|
225
|
Jak
|
Pi3k
|
0.00237150099487695
|
550.112700011199
|
23
|
61.368
|
1
|
4.77395900588817e-15
|
0
|
Jak_Pi3k
|
611.480700011199
|
10.04
|
|
5
|
220
|
Jak
|
Igfr
|
0.00212368313237165
|
550.179742880404
|
23
|
61.301
|
1
|
4.88498130835069e-15
|
0
|
Jak_Igfr
|
611.480742880404
|
10.03
|
|
6
|
213
|
Jak
|
Akt
|
0.00027839697601006
|
550.180441768978
|
23
|
61.3
|
1
|
4.88498130835069e-15
|
0
|
Jak_Akt
|
611.480441768978
|
10.02
|
|
7
|
317
|
Raf
|
Actr
|
0.995293695761167
|
551.201394840101
|
23
|
60.279
|
1
|
8.21565038222616e-15
|
0
|
Raf_Actr
|
611.480394840101
|
9.86
|
|
8
|
334
|
Raf
|
Smad2
|
0.995293695761167
|
551.201394840101
|
23
|
60.279
|
1
|
8.21565038222616e-15
|
0
|
Raf_Smad2
|
611.480394840101
|
9.86
|
|
9
|
338
|
Ras
|
Actr
|
0.995293695761167
|
551.201394840101
|
23
|
60.279
|
1
|
8.21565038222616e-15
|
0
|
Ras_Actr
|
611.480394840101
|
9.86
|
|
10
|
355
|
Ras
|
Smad2
|
0.995293695761167
|
551.201394840101
|
23
|
60.279
|
1
|
8.21565038222616e-15
|
0
|
Ras_Smad2
|
611.480394840101
|
9.86
|
|
11
|
149
|
Fgfr
|
Actr
|
1
|
551.261964847594
|
23
|
60.219
|
1
|
8.43769498715119e-15
|
0
|
Fgfr_Actr
|
611.480964847594
|
9.85
|
|
12
|
166
|
Fgfr
|
Smad2
|
1
|
551.261964847594
|
23
|
60.219
|
1
|
8.43769498715119e-15
|
0
|
Fgfr_Smad2
|
611.480964847594
|
9.85
|
|
13
|
254
|
Mek
|
Actr
|
0.593840281484033
|
552.874753568515
|
23
|
58.606
|
1
|
1.93178806284777e-14
|
0
|
Mek_Actr
|
611.480753568515
|
9.58
|
|
14
|
271
|
Mek
|
Smad2
|
0.593895601175709
|
552.876435578234
|
23
|
58.604
|
1
|
1.93178806284777e-14
|
0
|
Mek_Smad2
|
611.480435578234
|
9.58
|
|
15
|
107
|
Erk
|
Actr
|
0.126701455011672
|
552.878653223665
|
23
|
58.602
|
1
|
1.93178806284777e-14
|
0
|
Erk_Actr
|
611.480653223665
|
9.58
|
|
16
|
124
|
Erk
|
Smad2
|
0.126626186957925
|
552.881245925014
|
23
|
58.599
|
1
|
1.93178806284777e-14
|
0
|
Erk_Smad2
|
611.480245925014
|
9.58
|
|
17
|
227
|
Jak
|
Ras
|
-4.2666625868268
|
553.347992021564
|
23
|
58.133
|
1
|
2.4535928844216e-14
|
0
|
Jak_Ras
|
611.480992021564
|
9.51
|
|
18
|
226
|
Jak
|
Raf
|
-4.11677150532775
|
553.650811938468
|
23
|
57.83
|
1
|
2.85327317328665e-14
|
0
|
Jak_Raf
|
611.480811938468
|
9.46
|
|
19
|
223
|
Jak
|
Mek
|
-3.77256977290167
|
554.437419345944
|
23
|
57.043
|
1
|
4.2632564145606e-14
|
0
|
Jak_Mek
|
611.480419345944
|
9.33
|
|
20
|
179
|
Gsk3
|
Jak
|
0.119653035872602
|
562.645358518725
|
23
|
48.835
|
1
|
2.78388423424758e-12
|
0
|
Gsk3_Jak
|
611.480358518725
|
7.99
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
2
|
Jak_Gsk3
|
60.097
|
0
|
7.53
|
64.149
|
0
|
10.49
|
124.246
|
18.02
|
|
14
|
Bmp4r_Actr
|
35.077
|
0
|
4.39
|
81.343
|
0
|
13.3
|
116.42
|
17.69
|
|
15
|
Bmp4r_Smad2
|
35.077
|
0
|
4.39
|
81.343
|
0
|
13.3
|
116.42
|
17.69
|
|
1
|
Jak_Akt
|
60.146
|
0
|
7.53
|
61.3
|
0
|
10.02
|
121.446
|
17.55
|
|
4
|
Jak_Pi3k
|
59.943
|
0
|
7.51
|
61.368
|
0
|
10.04
|
121.311
|
17.55
|
|
3
|
Jak_Igfr
|
59.988
|
0
|
7.51
|
61.301
|
0
|
10.03
|
121.289
|
17.54
|
|
8
|
Raf_Actr
|
48.695
|
0
|
6.1
|
60.279
|
0
|
9.86
|
108.974
|
15.96
|
|
9
|
Ras_Smad2
|
48.695
|
0
|
6.1
|
60.279
|
0
|
9.86
|
108.974
|
15.96
|
|
10
|
Raf_Smad2
|
48.695
|
0
|
6.1
|
60.279
|
0
|
9.86
|
108.974
|
15.96
|
|
11
|
Ras_Actr
|
48.695
|
0
|
6.1
|
60.279
|
0
|
9.86
|
108.974
|
15.96
|
|
12
|
Fgfr_Actr
|
48.693
|
0
|
6.1
|
60.219
|
0
|
9.85
|
108.912
|
15.95
|
|
13
|
Fgfr_Smad2
|
48.693
|
0
|
6.1
|
60.219
|
0
|
9.85
|
108.912
|
15.95
|
|
5
|
Jak_Ras
|
48.704
|
0
|
6.1
|
58.133
|
0
|
9.51
|
106.837
|
15.61
|
|
7
|
Jak_Raf
|
48.704
|
0
|
6.1
|
57.83
|
0
|
9.46
|
106.534
|
15.56
|
|
6
|
Jak_Mek
|
48.704
|
0
|
6.1
|
57.043
|
0
|
9.33
|
105.747
|
15.43
|
|
16
|
Actr_Raf
|
34.759
|
0
|
4.35
|
44.809
|
0
|
7.33
|
79.568
|
11.68
|
|
17
|
Actr_Ras
|
34.759
|
0
|
4.35
|
44.809
|
0
|
7.33
|
79.568
|
11.68
|
|
18
|
Actr_Mek
|
34.759
|
0
|
4.35
|
44.809
|
0
|
7.33
|
79.568
|
11.68
|
|
21
|
Igfr_Actr
|
33.455
|
0
|
4.19
|
45.245
|
0
|
7.4
|
78.7
|
11.59
|
|
22
|
Igfr_Smad2
|
33.455
|
0
|
4.19
|
45.245
|
0
|
7.4
|
78.7
|
11.59
|
LA5
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
27
|
Actr
|
Erk
|
-0.72293860974715
|
676.169306265696
|
24
|
61.771
|
1
|
3.88578058618805e-15
|
0
|
Actr_Erk
|
737.940306265696
|
8.37
|
|
2
|
34
|
Actr
|
Mek
|
-0.166895406755719
|
691.240344479409
|
24
|
46.7
|
1
|
8.27227175648204e-12
|
0
|
Actr_Mek
|
737.940344479409
|
6.33
|
|
3
|
37
|
Actr
|
Raf
|
-0.166895406755719
|
691.240344479409
|
24
|
46.7
|
1
|
8.27227175648204e-12
|
0
|
Actr_Raf
|
737.940344479409
|
6.33
|
|
4
|
38
|
Actr
|
Ras
|
-0.166895406755719
|
691.240344479409
|
24
|
46.7
|
1
|
8.27227175648204e-12
|
0
|
Actr_Ras
|
737.940344479409
|
6.33
|
|
5
|
86
|
Bmp4r
|
Actr
|
1.46213132226849
|
692.141349173648
|
24
|
45.799
|
1
|
1.31020749805089e-11
|
0
|
Bmp4r_Actr
|
737.940349173648
|
6.21
|
|
6
|
103
|
Bmp4r
|
Smad2
|
1.46203089405264
|
692.142403593777
|
24
|
45.798
|
1
|
1.3109069385564e-11
|
0
|
Bmp4r_Smad2
|
737.940403593777
|
6.21
|
|
7
|
26
|
Actr
|
Bmp4r
|
-0.369203746740597
|
697.322620742319
|
24
|
40.618
|
1
|
1.85105042405098e-10
|
0
|
Actr_Bmp4r
|
737.940620742319
|
5.5
|
|
8
|
29
|
Actr
|
Fgfr
|
-0.192327175159802
|
697.904213328672
|
24
|
40.036
|
1
|
2.4928847874861e-10
|
0
|
Actr_Fgfr
|
737.940213328672
|
5.43
|
|
9
|
208
|
Igfr
|
Smad2
|
0.251402223524026
|
703.799197742007
|
24
|
34.141
|
1
|
5.12517772666143e-09
|
0
|
Igfr_Smad2
|
737.940197742007
|
4.63
|
|
10
|
191
|
Igfr
|
Actr
|
0.251401619614044
|
703.799199571605
|
24
|
34.141
|
1
|
5.12518261164274e-09
|
0
|
Igfr_Actr
|
737.940199571605
|
4.63
|
|
11
|
313
|
Pi3k
|
Smad2
|
0.298899509996016
|
703.825793426311
|
24
|
34.115
|
1
|
5.19570664270219e-09
|
0
|
Pi3k_Smad2
|
737.940793426311
|
4.62
|
|
12
|
296
|
Pi3k
|
Actr
|
0.298897600445779
|
703.825883930459
|
24
|
34.115
|
1
|
5.19594833825465e-09
|
0
|
Pi3k_Actr
|
737.940883930459
|
4.62
|
|
13
|
187
|
Gsk3
|
Smad2
|
0.252836828250392
|
703.844981193709
|
24
|
34.096
|
1
|
5.24719334649149e-09
|
0
|
Gsk3_Smad2
|
737.940981193709
|
4.62
|
|
14
|
170
|
Gsk3
|
Actr
|
0.252731135219506
|
703.848696618809
|
24
|
34.092
|
1
|
5.25722188005062e-09
|
0
|
Gsk3_Actr
|
737.940696618809
|
4.62
|
|
15
|
61
|
Akt
|
Smad2
|
0.117804022253642
|
703.872140488639
|
24
|
34.068
|
1
|
5.32094479588352e-09
|
0
|
Akt_Smad2
|
737.940140488639
|
4.62
|
|
16
|
44
|
Akt
|
Actr
|
0.117804022251717
|
703.872140503707
|
24
|
34.068
|
1
|
5.32094479588352e-09
|
0
|
Akt_Actr
|
737.940140503707
|
4.62
|
|
17
|
422
|
mTor
|
Actr
|
0.512680275440013
|
703.921106637597
|
24
|
34.019
|
1
|
5.45654610384361e-09
|
0
|
mTor_Actr
|
737.940106637597
|
4.61
|
|
18
|
439
|
mTor
|
Smad2
|
0.512680275484112
|
703.921106722922
|
24
|
34.019
|
1
|
5.45654632588821e-09
|
0
|
mTor_Smad2
|
737.940106722922
|
4.61
|
|
19
|
166
|
Fgfr
|
Smad2
|
0.137321430594518
|
708.310590445347
|
24
|
29.63
|
1
|
5.22917706913262e-08
|
0
|
Fgfr_Smad2
|
737.940590445347
|
4.02
|
|
20
|
149
|
Fgfr
|
Actr
|
0.137321429933222
|
708.310590544031
|
24
|
29.63
|
1
|
5.22917733558614e-08
|
0
|
Fgfr_Actr
|
737.940590544031
|
4.02
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
103
|
Bmp4r
|
Smad2
|
0.184039407308206
|
465.989068855463
|
24
|
81.343
|
1
|
0
|
0
|
Bmp4r_Smad2
|
547.332068855463
|
14.86
|
|
2
|
86
|
Bmp4r
|
Actr
|
0.18401069929792
|
465.989068858964
|
24
|
81.343
|
1
|
0
|
0
|
Bmp4r_Actr
|
547.332068858964
|
14.86
|
|
3
|
166
|
Fgfr
|
Smad2
|
0.787412501709583
|
487.061034123738
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Fgfr_Smad2
|
547.332034123738
|
11.01
|
|
4
|
338
|
Ras
|
Actr
|
0.787396035446579
|
487.06103412831
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Ras_Actr
|
547.33203412831
|
11.01
|
|
5
|
334
|
Raf
|
Smad2
|
0.787401177145844
|
487.061034129885
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Raf_Smad2
|
547.332034129885
|
11.01
|
|
6
|
317
|
Raf
|
Actr
|
0.787447609308935
|
487.061034156285
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Raf_Actr
|
547.332034156285
|
11.01
|
|
7
|
149
|
Fgfr
|
Actr
|
0.787387354758698
|
487.061034164812
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Fgfr_Actr
|
547.332034164812
|
11.01
|
|
8
|
355
|
Ras
|
Smad2
|
0.787439992189182
|
487.061034172604
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Ras_Smad2
|
547.332034172604
|
11.01
|
|
9
|
254
|
Mek
|
Actr
|
0.543844924532893
|
493.382476011324
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Mek_Actr
|
547.331476011324
|
9.86
|
|
10
|
124
|
Erk
|
Smad2
|
0.123251777854743
|
493.382476050697
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Erk_Smad2
|
547.331476050697
|
9.86
|
|
11
|
107
|
Erk
|
Actr
|
0.123252069043532
|
493.382476054152
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Erk_Actr
|
547.331476054152
|
9.86
|
|
12
|
271
|
Mek
|
Smad2
|
0.543845016513122
|
493.382476119721
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Mek_Smad2
|
547.331476119721
|
9.86
|
|
13
|
180
|
Gsk3
|
Lifr
|
0.254069080523393
|
498.901017903447
|
24
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Lifr
|
547.332017903447
|
8.85
|
|
14
|
179
|
Gsk3
|
Jak
|
0.2540693850344
|
498.901018150175
|
24
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Jak
|
547.332018150175
|
8.85
|
|
15
|
200
|
Igfr
|
Jak
|
0.394644138994172
|
502.069365669424
|
24
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Jak
|
547.331365669424
|
8.27
|
|
16
|
201
|
Igfr
|
Lifr
|
0.394606918882979
|
502.069365777655
|
24
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Lifr
|
547.331365777655
|
8.27
|
|
17
|
29
|
Actr
|
Fgfr
|
-0.0929468005033651
|
502.642865761317
|
24
|
44.689
|
1
|
2.30960806035796e-11
|
0
|
Actr_Fgfr
|
547.331865761317
|
8.16
|
|
18
|
26
|
Actr
|
Bmp4r
|
-0.000417559481493501
|
502.643828256366
|
24
|
44.688
|
1
|
2.31075159007332e-11
|
0
|
Actr_Bmp4r
|
547.331828256366
|
8.16
|
|
19
|
25
|
Actr
|
Bmp4
|
-0.000417568834700513
|
502.643828269157
|
24
|
44.688
|
1
|
2.31075159007332e-11
|
0
|
Actr_Bmp4
|
547.331828269157
|
8.16
|
|
20
|
34
|
Actr
|
Mek
|
-0.766281477217178
|
503.920691844864
|
24
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Mek
|
547.331691844864
|
7.93
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
4
|
Bmp4r_Actr
|
45.799
|
0
|
6.21
|
81.343
|
0
|
14.86
|
127.142
|
21.07
|
|
5
|
Bmp4r_Smad2
|
45.798
|
0
|
6.21
|
81.343
|
0
|
14.86
|
127.141
|
21.07
|
|
18
|
Fgfr_Smad2
|
29.63
|
0
|
4.02
|
60.271
|
0
|
11.01
|
89.901
|
15.03
|
|
19
|
Fgfr_Actr
|
29.63
|
0
|
4.02
|
60.271
|
0
|
11.01
|
89.901
|
15.03
|
|
20
|
Ras_Actr
|
27.417
|
0
|
3.72
|
60.271
|
0
|
11.01
|
87.688
|
14.73
|
|
21
|
Raf_Smad2
|
27.417
|
0
|
3.72
|
60.271
|
0
|
11.01
|
87.688
|
14.73
|
|
22
|
Ras_Smad2
|
27.417
|
0
|
3.72
|
60.271
|
0
|
11.01
|
87.688
|
14.73
|
|
23
|
Raf_Actr
|
27.417
|
0
|
3.72
|
60.271
|
0
|
11.01
|
87.688
|
14.73
|
|
1
|
Actr_Mek
|
46.7
|
0
|
6.33
|
43.411
|
0
|
7.93
|
90.111
|
14.26
|
|
2
|
Actr_Raf
|
46.7
|
0
|
6.33
|
43.411
|
0
|
7.93
|
90.111
|
14.26
|
|
3
|
Actr_Ras
|
46.7
|
0
|
6.33
|
43.411
|
0
|
7.93
|
90.111
|
14.26
|
|
6
|
Actr_Bmp4r
|
40.618
|
0
|
5.5
|
44.688
|
0
|
8.16
|
85.306
|
13.66
|
|
7
|
Actr_Fgfr
|
40.036
|
0
|
5.43
|
44.689
|
0
|
8.16
|
84.725
|
13.59
|
|
27
|
Gsk3_Lifr
|
24.321
|
0
|
3.3
|
48.431
|
0
|
8.85
|
72.752
|
12.15
|
|
29
|
Gsk3_Jak
|
22.73
|
0.001
|
3.08
|
48.431
|
0
|
8.85
|
71.161
|
11.93
|
|
8
|
Igfr_Smad2
|
34.141
|
0
|
4.63
|
38.974
|
0
|
7.12
|
73.115
|
11.75
|
|
9
|
Igfr_Actr
|
34.141
|
0
|
4.63
|
38.974
|
0
|
7.12
|
73.115
|
11.75
|
|
12
|
Gsk3_Smad2
|
34.096
|
0
|
4.62
|
38.911
|
0
|
7.11
|
73.007
|
11.73
|
|
13
|
Gsk3_Actr
|
34.092
|
0
|
4.62
|
38.911
|
0
|
7.11
|
73.003
|
11.73
|
|
24
|
Igfr_Lifr
|
24.367
|
0
|
3.3
|
45.262
|
0
|
8.27
|
69.629
|
11.57
|
LA6
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
27
|
Actr
|
Erk
|
-0.371797470550757
|
644.66350691414
|
25
|
47.209
|
1
|
6.38056274482324e-12
|
0
|
Actr_Erk
|
691.87250691414
|
6.82
|
|
2
|
37
|
Actr
|
Raf
|
-0.161981281597708
|
645.878577216417
|
25
|
45.994
|
1
|
1.18618448397001e-11
|
0
|
Actr_Raf
|
691.872577216417
|
6.65
|
|
3
|
38
|
Actr
|
Ras
|
-0.161981281597708
|
645.878577216417
|
25
|
45.994
|
1
|
1.18618448397001e-11
|
0
|
Actr_Ras
|
691.872577216417
|
6.65
|
|
4
|
34
|
Actr
|
Mek
|
-0.16197557293187
|
645.880509363129
|
25
|
45.992
|
1
|
1.18736132037611e-11
|
0
|
Actr_Mek
|
691.872509363129
|
6.65
|
|
5
|
29
|
Actr
|
Fgfr
|
-1.08636633192704
|
652.414723689582
|
25
|
39.458
|
1
|
3.35225180947418e-10
|
0
|
Actr_Fgfr
|
691.872723689582
|
5.7
|
|
6
|
194
|
Igfr
|
Bmp4r
|
8.75867295528011
|
660.382843487529
|
25
|
31.49
|
1
|
2.00502497937904e-08
|
0
|
Igfr_Bmp4r
|
691.872843487529
|
4.55
|
|
7
|
173
|
Gsk3
|
Bmp4r
|
7.97385173700289
|
662.907023443208
|
25
|
28.966
|
1
|
7.36786811561529e-08
|
0
|
Gsk3_Bmp4r
|
691.873023443208
|
4.19
|
|
8
|
47
|
Akt
|
Bmp4r
|
0.717958514203464
|
665.709742264527
|
25
|
26.163
|
1
|
3.13812181462758e-07
|
0
|
Akt_Bmp4r
|
691.872742264527
|
3.78
|
|
9
|
201
|
Igfr
|
Lifr
|
1.75521212473151
|
667.546249096471
|
25
|
24.326
|
1
|
8.13219817707989e-07
|
0
|
Igfr_Lifr
|
691.872249096471
|
3.52
|
|
10
|
200
|
Igfr
|
Jak
|
2.03708486202796
|
667.564188397286
|
25
|
24.308
|
1
|
8.20828729986012e-07
|
0
|
Igfr_Jak
|
691.872188397286
|
3.51
|
|
11
|
54
|
Akt
|
Lifr
|
0.672753595187013
|
667.58569830976
|
25
|
24.287
|
1
|
8.30046285371644e-07
|
0
|
Akt_Lifr
|
691.87269830976
|
3.51
|
|
12
|
53
|
Akt
|
Jak
|
0.506206184016253
|
667.60846544661
|
25
|
24.264
|
1
|
8.39915692441018e-07
|
0
|
Akt_Jak
|
691.87246544661
|
3.51
|
|
13
|
299
|
Pi3k
|
Bmp4r
|
1.00012390475789
|
667.833350611076
|
25
|
24.039
|
1
|
9.43952919385538e-07
|
0
|
Pi3k_Bmp4r
|
691.872350611076
|
3.47
|
|
14
|
117
|
Erk
|
Lifr
|
0.24608608080984
|
668.802487795973
|
25
|
23.07
|
1
|
1.56205748969018e-06
|
0.001
|
Erk_Lifr
|
691.872487795973
|
3.33
|
|
15
|
263
|
Mek
|
Jak
|
0.83373898716997
|
668.859559779302
|
25
|
23.013
|
1
|
1.60912209634656e-06
|
0.001
|
Mek_Jak
|
691.872559779302
|
3.33
|
|
16
|
116
|
Erk
|
Jak
|
0.248071549067934
|
668.89449384246
|
25
|
22.978
|
1
|
1.63862969770889e-06
|
0.001
|
Erk_Jak
|
691.87249384246
|
3.32
|
|
17
|
264
|
Mek
|
Lifr
|
1.14864753452585
|
669.026816841791
|
25
|
22.846
|
1
|
1.75540514424366e-06
|
0.001
|
Mek_Lifr
|
691.872816841791
|
3.3
|
|
18
|
179
|
Gsk3
|
Jak
|
0.99995245696994
|
669.350639924256
|
25
|
22.522
|
1
|
2.07762634030217e-06
|
0.001
|
Gsk3_Jak
|
691.872639924256
|
3.26
|
|
19
|
305
|
Pi3k
|
Jak
|
1.0000698464452
|
669.47174704781
|
25
|
22.401
|
1
|
2.21283907531067e-06
|
0.001
|
Pi3k_Jak
|
691.87274704781
|
3.24
|
|
20
|
240
|
Lifr
|
Gsk3
|
0.011950396789722
|
669.95833928296
|
25
|
21.914
|
1
|
2.85117875542529e-06
|
0.001
|
Lifr_Gsk3
|
691.87233928296
|
3.17
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
179
|
Gsk3
|
Jak
|
0.254068951082065
|
417.558306756105
|
25
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Jak
|
465.989306756105
|
10.39
|
|
2
|
180
|
Gsk3
|
Lifr
|
0.254071104301913
|
417.558306834712
|
25
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Lifr
|
465.989306834712
|
10.39
|
|
3
|
201
|
Igfr
|
Lifr
|
0.394542656867191
|
420.726654719223
|
25
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Lifr
|
465.988654719223
|
9.71
|
|
4
|
200
|
Igfr
|
Jak
|
0.3944863064986
|
420.726655148809
|
25
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Jak
|
465.988655148809
|
9.71
|
|
5
|
29
|
Actr
|
Fgfr
|
-0.092945624966265
|
421.300154446345
|
25
|
44.689
|
1
|
2.30960806035796e-11
|
0
|
Actr_Fgfr
|
465.989154446345
|
9.59
|
|
6
|
26
|
Actr
|
Bmp4r
|
-0.00014014367166331
|
421.302820869133
|
25
|
44.686
|
1
|
2.3127610937479e-11
|
0
|
Actr_Bmp4r
|
465.988820869133
|
9.59
|
|
7
|
25
|
Actr
|
Bmp4
|
-0.000140135825763944
|
421.302822364256
|
25
|
44.686
|
1
|
2.3127610937479e-11
|
0
|
Actr_Bmp4
|
465.988822364256
|
9.59
|
|
8
|
37
|
Actr
|
Raf
|
-0.766283034702303
|
422.577980657324
|
25
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Raf
|
465.988980657324
|
9.32
|
|
9
|
38
|
Actr
|
Ras
|
-0.766283034702303
|
422.577980657324
|
25
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Ras
|
465.988980657324
|
9.32
|
|
10
|
34
|
Actr
|
Mek
|
-0.766283054935296
|
422.57798066996
|
25
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Mek
|
465.98898066996
|
9.32
|
|
11
|
432
|
mTor
|
Lifr
|
0.609537372287292
|
431.486851177641
|
25
|
34.502
|
1
|
4.25765978029347e-09
|
0
|
mTor_Lifr
|
465.988851177641
|
7.4
|
|
12
|
306
|
Pi3k
|
Lifr
|
0.0226219239784875
|
431.486851254867
|
25
|
34.502
|
1
|
4.25765989131577e-09
|
0
|
Pi3k_Lifr
|
465.988851254867
|
7.4
|
|
13
|
53
|
Akt
|
Jak
|
0.740798903405232
|
431.486851266564
|
25
|
34.502
|
1
|
4.25765989131577e-09
|
0
|
Akt_Jak
|
465.988851266564
|
7.4
|
|
14
|
54
|
Akt
|
Lifr
|
0.740869371270705
|
431.486851693862
|
25
|
34.502
|
1
|
4.25766089051649e-09
|
0
|
Akt_Lifr
|
465.988851693862
|
7.4
|
|
15
|
431
|
mTor
|
Jak
|
0.609455105791309
|
431.486851712281
|
25
|
34.502
|
1
|
4.25766089051649e-09
|
0
|
mTor_Jak
|
465.988851712281
|
7.4
|
|
16
|
305
|
Pi3k
|
Jak
|
0.0225812936289245
|
431.486852171322
|
25
|
34.502
|
1
|
4.25766188971721e-09
|
0
|
Pi3k_Jak
|
465.988852171322
|
7.4
|
|
17
|
188
|
Gsk3
|
Stat3
|
0.159951039589571
|
432.097840178762
|
25
|
33.891
|
1
|
5.828086124815e-09
|
0
|
Gsk3_Stat3
|
465.988840178762
|
7.27
|
|
18
|
194
|
Igfr
|
Bmp4r
|
4.12002839867408
|
433.320218026849
|
25
|
32.669
|
1
|
1.0927446059128e-08
|
0
|
Igfr_Bmp4r
|
465.989218026849
|
7.01
|
|
19
|
193
|
Igfr
|
Bmp4
|
1
|
433.320218073108
|
25
|
32.669
|
1
|
1.09274462811726e-08
|
0
|
Igfr_Bmp4
|
465.989218073108
|
7.01
|
|
20
|
173
|
Gsk3
|
Bmp4r
|
5.49572235294527
|
436.465615936059
|
25
|
29.523
|
1
|
5.52441584700247e-08
|
0
|
Gsk3_Bmp4r
|
465.988615936059
|
6.34
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Actr_Raf
|
45.994
|
0
|
6.65
|
43.411
|
0
|
9.32
|
89.405
|
15.97
|
|
2
|
Actr_Ras
|
45.994
|
0
|
6.65
|
43.411
|
0
|
9.32
|
89.405
|
15.97
|
|
3
|
Actr_Mek
|
45.992
|
0
|
6.65
|
43.411
|
0
|
9.32
|
89.403
|
15.97
|
|
4
|
Actr_Fgfr
|
39.458
|
0
|
5.7
|
44.689
|
0
|
9.59
|
84.147
|
15.29
|
|
13
|
Gsk3_Jak
|
22.522
|
0.001
|
3.26
|
48.431
|
0
|
10.39
|
70.953
|
13.65
|
|
8
|
Igfr_Lifr
|
24.326
|
0
|
3.52
|
45.262
|
0
|
9.71
|
69.588
|
13.23
|
|
9
|
Igfr_Jak
|
24.308
|
0
|
3.51
|
45.262
|
0
|
9.71
|
69.57
|
13.22
|
|
16
|
Actr_Bmp4r
|
20.816
|
0.002
|
3.01
|
44.686
|
0
|
9.59
|
65.502
|
12.6
|
|
5
|
Igfr_Bmp4r
|
31.49
|
0
|
4.55
|
32.669
|
0
|
7.01
|
64.159
|
11.56
|
|
10
|
Akt_Lifr
|
24.287
|
0
|
3.51
|
34.502
|
0
|
7.4
|
58.789
|
10.91
|
|
11
|
Akt_Jak
|
24.264
|
0
|
3.51
|
34.502
|
0
|
7.4
|
58.766
|
10.91
|
|
14
|
Pi3k_Jak
|
22.401
|
0.001
|
3.24
|
34.502
|
0
|
7.4
|
56.903
|
10.64
|
|
6
|
Gsk3_Bmp4r
|
28.966
|
0
|
4.19
|
29.523
|
0
|
6.34
|
58.489
|
10.53
|
|
23
|
mTor_Jak
|
17.571
|
0.009
|
2.54
|
34.502
|
0
|
7.4
|
52.073
|
9.94
|
|
21
|
Gsk3_Stat3
|
18.305
|
0.006
|
2.65
|
33.891
|
0
|
7.27
|
52.196
|
9.92
|
|
7
|
Akt_Bmp4r
|
26.163
|
0
|
3.78
|
27.087
|
0
|
5.81
|
53.25
|
9.59
|
|
12
|
Pi3k_Bmp4r
|
24.039
|
0
|
3.47
|
27.087
|
0
|
5.81
|
51.126
|
9.28
|
|
24
|
Igfr_Stat3
|
17.524
|
0.01
|
2.53
|
28.594
|
0
|
6.14
|
46.118
|
8.67
|
|
15
|
Lifr_Gsk3
|
21.914
|
0.001
|
3.17
|
24.748
|
0
|
5.31
|
46.662
|
8.48
|
|
22
|
mTor_Bmp4r
|
17.982
|
0.008
|
2.6
|
27.087
|
0
|
5.81
|
45.069
|
8.41
|
LA7
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
116
|
Erk
|
Jak
|
0.478092151777645
|
622.890849891522
|
26
|
22.186
|
1
|
2.47444245271566e-06
|
0.001
|
Erk_Jak
|
645.076849891522
|
3.44
|
|
2
|
117
|
Erk
|
Lifr
|
0.47577560738498
|
622.908363089392
|
26
|
22.169
|
1
|
2.49711746791448e-06
|
0.001
|
Erk_Lifr
|
645.077363089392
|
3.44
|
|
3
|
54
|
Akt
|
Lifr
|
1.13010959589657
|
625.348599860944
|
26
|
19.728
|
1
|
8.92619281955831e-06
|
0.003
|
Akt_Lifr
|
645.076599860944
|
3.06
|
|
4
|
53
|
Akt
|
Jak
|
1.1305206470739
|
625.38973354965
|
26
|
19.687
|
1
|
9.12040688494375e-06
|
0.003
|
Akt_Jak
|
645.07673354965
|
3.05
|
|
5
|
110
|
Erk
|
Bmp4r
|
0.665190083093769
|
626.174236478189
|
26
|
18.903
|
1
|
1.37548687854094e-05
|
0.005
|
Erk_Bmp4r
|
645.077236478189
|
2.93
|
|
6
|
263
|
Mek
|
Jak
|
1.00112015417932
|
626.311279040538
|
26
|
18.766
|
1
|
1.47795007953144e-05
|
0.005
|
Mek_Jak
|
645.077279040538
|
2.91
|
|
7
|
240
|
Lifr
|
Gsk3
|
0.00656006894227856
|
626.371419277829
|
26
|
18.706
|
1
|
1.52530331597456e-05
|
0.005
|
Lifr_Gsk3
|
645.077419277829
|
2.9
|
|
8
|
234
|
Lifr
|
Akt
|
0.0050438521289888
|
626.409471590698
|
26
|
18.668
|
1
|
1.55604909786167e-05
|
0.005
|
Lifr_Akt
|
645.077471590698
|
2.89
|
|
9
|
215
|
Jak
|
Bmp4r
|
0.118761187021543
|
626.42147542289
|
26
|
18.656
|
1
|
1.56587661087615e-05
|
0.005
|
Jak_Bmp4r
|
645.07747542289
|
2.89
|
|
10
|
246
|
Lifr
|
Pi3k
|
0.000377337007281183
|
626.645679302902
|
26
|
18.431
|
1
|
1.76133060604267e-05
|
0.006
|
Lifr_Pi3k
|
645.076679302902
|
2.86
|
|
11
|
314
|
Pi3k
|
Stat3
|
0.246120924039924
|
626.822103850259
|
26
|
18.255
|
1
|
1.93222196843701e-05
|
0.006
|
Pi3k_Stat3
|
645.077103850259
|
2.83
|
|
12
|
62
|
Akt
|
Stat3
|
0.0897525803818863
|
626.871425969851
|
26
|
18.206
|
1
|
1.98291032349474e-05
|
0.007
|
Akt_Stat3
|
645.077425969851
|
2.82
|
|
13
|
201
|
Igfr
|
Lifr
|
4.01886872429972
|
626.877634511713
|
26
|
18.199
|
1
|
1.98938479170074e-05
|
0.007
|
Igfr_Lifr
|
645.076634511713
|
2.82
|
|
14
|
200
|
Igfr
|
Jak
|
4.24847786105488
|
626.885884362503
|
26
|
18.191
|
1
|
1.99802087433865e-05
|
0.007
|
Igfr_Jak
|
645.076884362503
|
2.82
|
|
15
|
188
|
Gsk3
|
Stat3
|
0.193316748343431
|
626.893176019978
|
26
|
18.184
|
1
|
2.0056852544581e-05
|
0.007
|
Gsk3_Stat3
|
645.077176019978
|
2.82
|
|
16
|
209
|
Igfr
|
Stat3
|
0.187893300128126
|
626.934839271513
|
26
|
18.142
|
1
|
2.05004817299681e-05
|
0.007
|
Igfr_Stat3
|
645.076839271513
|
2.81
|
|
17
|
241
|
Lifr
|
Igfr
|
0.00133113033908252
|
627.435893266719
|
26
|
17.641
|
1
|
2.66750811849237e-05
|
0.009
|
Lifr_Igfr
|
645.076893266719
|
2.73
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
180
|
Gsk3
|
Lifr
|
0.204449789427288
|
386.280620890445
|
26
|
36.297
|
1
|
1.69393199467294e-09
|
0
|
Gsk3_Lifr
|
422.577620890445
|
8.59
|
|
2
|
179
|
Gsk3
|
Jak
|
0.204451759095846
|
386.280621082363
|
26
|
36.297
|
1
|
1.69393221671754e-09
|
0
|
Gsk3_Jak
|
422.577621082363
|
8.59
|
|
3
|
188
|
Gsk3
|
Stat3
|
0.160457470553098
|
388.755973945851
|
26
|
33.822
|
1
|
6.03918448582874e-09
|
0
|
Gsk3_Stat3
|
422.577973945851
|
8
|
|
4
|
200
|
Igfr
|
Jak
|
0.329294397141902
|
390.071887880546
|
26
|
32.506
|
1
|
1.18819449834717e-08
|
0
|
Igfr_Jak
|
422.577887880546
|
7.69
|
|
5
|
201
|
Igfr
|
Lifr
|
0.32928440535087
|
390.071887918402
|
26
|
32.506
|
1
|
1.18819452055163e-08
|
0
|
Igfr_Lifr
|
422.577887918402
|
7.69
|
|
6
|
209
|
Igfr
|
Stat3
|
0.231612782637007
|
394.043515363579
|
26
|
28.534
|
1
|
9.20453719910341e-08
|
0
|
Igfr_Stat3
|
422.577515363579
|
6.75
|
|
7
|
234
|
Lifr
|
Akt
|
0.0462196227783465
|
396.116365997349
|
26
|
26.462
|
1
|
2.68827251015402e-07
|
0
|
Lifr_Akt
|
422.578365997349
|
6.26
|
|
8
|
241
|
Lifr
|
Igfr
|
0.135793139520361
|
396.668918218988
|
26
|
25.909
|
1
|
3.57885072022057e-07
|
0
|
Lifr_Igfr
|
422.577918218988
|
6.13
|
|
9
|
246
|
Lifr
|
Pi3k
|
1.28992919217763
|
396.763764952033
|
26
|
25.814
|
1
|
3.75909642080785e-07
|
0
|
Lifr_Pi3k
|
422.577764952033
|
6.11
|
|
10
|
240
|
Lifr
|
Gsk3
|
0.122360298845118
|
396.926697951235
|
26
|
25.651
|
1
|
4.09023558134436e-07
|
0
|
Lifr_Gsk3
|
422.577697951235
|
6.07
|
|
11
|
432
|
mTor
|
Lifr
|
0.469152832603995
|
398.054726959083
|
26
|
24.523
|
1
|
7.34184159245643e-07
|
0
|
mTor_Lifr
|
422.577726959083
|
5.8
|
|
12
|
305
|
Pi3k
|
Jak
|
0.017433244009084
|
398.054727206694
|
26
|
24.523
|
1
|
7.341842536146e-07
|
0
|
Pi3k_Jak
|
422.577727206694
|
5.8
|
|
13
|
306
|
Pi3k
|
Lifr
|
0.017431204338884
|
398.054727217841
|
26
|
24.523
|
1
|
7.34184257833448e-07
|
0
|
Pi3k_Lifr
|
422.577727217841
|
5.8
|
|
14
|
53
|
Akt
|
Jak
|
0.570660129762602
|
398.054727401473
|
26
|
24.523
|
1
|
7.34184327777498e-07
|
0
|
Akt_Jak
|
422.577727401473
|
5.8
|
|
15
|
431
|
mTor
|
Jak
|
0.469146155189099
|
398.054728085877
|
26
|
24.523
|
1
|
7.34184588568887e-07
|
0
|
mTor_Jak
|
422.577728085877
|
5.8
|
|
16
|
54
|
Akt
|
Lifr
|
0.57064380819813
|
398.054728096347
|
26
|
24.523
|
1
|
7.3418459256569e-07
|
0
|
Akt_Lifr
|
422.577728096347
|
5.8
|
|
17
|
215
|
Jak
|
Bmp4r
|
4.88316715651447
|
400.441643474264
|
26
|
22.136
|
1
|
2.53956951390411e-06
|
0.001
|
Jak_Bmp4r
|
422.577643474264
|
5.24
|
|
18
|
214
|
Jak
|
Bmp4
|
1
|
400.44164348852
|
26
|
22.136
|
1
|
2.5395695327779e-06
|
0.001
|
Jak_Bmp4
|
422.57764348852
|
5.24
|
|
19
|
440
|
mTor
|
Stat3
|
0.376841720934728
|
400.66644296426
|
26
|
21.912
|
1
|
2.8551218934636e-06
|
0.001
|
mTor_Stat3
|
422.57844296426
|
5.19
|
|
20
|
62
|
Akt
|
Stat3
|
0.458334601430997
|
400.666443018616
|
26
|
21.912
|
1
|
2.85512197428783e-06
|
0.001
|
Akt_Stat3
|
422.578443018616
|
5.19
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
11
|
Gsk3_Stat3
|
18.184
|
0.007
|
2.82
|
33.822
|
0
|
8
|
52.006
|
10.82
|
|
9
|
Igfr_Lifr
|
18.199
|
0.007
|
2.82
|
32.506
|
0
|
7.69
|
50.705
|
10.51
|
|
10
|
Igfr_Jak
|
18.191
|
0.007
|
2.82
|
32.506
|
0
|
7.69
|
50.697
|
10.51
|
|
12
|
Igfr_Stat3
|
18.142
|
0.007
|
2.81
|
28.534
|
0
|
6.75
|
46.676
|
9.56
|
|
4
|
Lifr_Akt
|
18.668
|
0.005
|
2.89
|
26.462
|
0
|
6.26
|
45.13
|
9.15
|
|
3
|
Lifr_Gsk3
|
18.706
|
0.005
|
2.9
|
25.651
|
0
|
6.07
|
44.357
|
8.97
|
|
6
|
Lifr_Pi3k
|
18.431
|
0.006
|
2.86
|
25.814
|
0
|
6.11
|
44.245
|
8.97
|
|
1
|
Akt_Lifr
|
19.728
|
0.003
|
3.06
|
24.523
|
0
|
5.8
|
44.251
|
8.86
|
|
13
|
Lifr_Igfr
|
17.641
|
0.009
|
2.73
|
25.909
|
0
|
6.13
|
43.55
|
8.86
|
|
2
|
Akt_Jak
|
19.687
|
0.003
|
3.05
|
24.523
|
0
|
5.8
|
44.21
|
8.85
|
|
5
|
Jak_Bmp4r
|
18.656
|
0.005
|
2.89
|
22.136
|
0.001
|
5.24
|
40.792
|
8.13
|
|
7
|
Pi3k_Stat3
|
18.255
|
0.006
|
2.83
|
21.912
|
0.001
|
5.19
|
40.167
|
8.02
|
|
8
|
Akt_Stat3
|
18.206
|
0.007
|
2.82
|
21.912
|
0.001
|
5.19
|
40.118
|
8.01
|
LA8
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
240
|
Lifr
|
Gsk3
|
0.0123762772846946
|
603.698920221329
|
27
|
23.144
|
1
|
1.502922328811e-06
|
0.001
|
Lifr_Gsk3
|
626.842920221329
|
3.69
|
|
2
|
250
|
Lifr
|
Smad2
|
-0.211558680003902
|
607.729688477853
|
27
|
19.113
|
1
|
1.23171977312042e-05
|
0.004
|
Lifr_Smad2
|
626.842688477853
|
3.05
|
|
3
|
246
|
Lifr
|
Pi3k
|
0.0012827875580377
|
608.433015651597
|
27
|
18.41
|
1
|
1.78106644715958e-05
|
0.006
|
Lifr_Pi3k
|
626.843015651597
|
2.94
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
240
|
Lifr
|
Gsk3
|
0.340156823652642
|
363.043453403628
|
27
|
25.713
|
1
|
3.96247964329355e-07
|
0
|
Lifr_Gsk3
|
388.756453403628
|
6.61
|
|
2
|
234
|
Lifr
|
Akt
|
0.0864753723916127
|
365.592813384858
|
27
|
23.163
|
1
|
1.48821191259252e-06
|
0
|
Lifr_Akt
|
388.755813384858
|
5.96
|
|
3
|
215
|
Jak
|
Bmp4r
|
4.83051262964478
|
366.702300375898
|
27
|
22.054
|
1
|
2.65131796972629e-06
|
0.001
|
Jak_Bmp4r
|
388.756300375898
|
5.67
|
|
4
|
214
|
Jak
|
Bmp4
|
1
|
366.702300553851
|
27
|
22.054
|
1
|
2.65131821552966e-06
|
0.001
|
Jak_Bmp4
|
388.756300553851
|
5.67
|
|
5
|
241
|
Lifr
|
Igfr
|
0.27820929917877
|
367.213569958621
|
27
|
21.542
|
1
|
3.46090791081277e-06
|
0.001
|
Lifr_Igfr
|
388.755569958621
|
5.54
|
|
6
|
246
|
Lifr
|
Pi3k
|
3.55867955091611
|
367.302683590274
|
27
|
21.453
|
1
|
3.62553376898056e-06
|
0.001
|
Lifr_Pi3k
|
388.755683590274
|
5.52
|
|
7
|
212
|
Jak
|
Actr
|
1
|
369.108604978772
|
27
|
19.647
|
1
|
9.31314655272519e-06
|
0.003
|
Jak_Actr
|
388.755604978772
|
5.05
|
|
8
|
229
|
Jak
|
Smad2
|
0.129255806208675
|
369.295363793503
|
27
|
19.461
|
1
|
1.0269577858657e-05
|
0.003
|
Jak_Smad2
|
388.756363793503
|
5.01
|
|
9
|
244
|
Lifr
|
Mek
|
-0.968537585229697
|
370.900682116607
|
27
|
17.855
|
1
|
2.38355523596301e-05
|
0.008
|
Lifr_Mek
|
388.755682116607
|
4.59
|
|
10
|
247
|
Lifr
|
Raf
|
-0.968536806593504
|
370.900682128888
|
27
|
17.855
|
1
|
2.3835552513507e-05
|
0.008
|
Lifr_Raf
|
388.755682128888
|
4.59
|
|
11
|
248
|
Lifr
|
Ras
|
-0.968538678607798
|
370.900682132306
|
27
|
17.855
|
1
|
2.38355525562506e-05
|
0.008
|
Lifr_Ras
|
388.755682132306
|
4.59
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Lifr_Gsk3
|
23.144
|
0.001
|
3.69
|
25.713
|
0
|
6.61
|
48.857
|
10.3
|
|
2
|
Lifr_Pi3k
|
18.41
|
0.006
|
2.94
|
21.453
|
0.001
|
5.52
|
39.863
|
8.46
|
LA9
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
215
|
Jak
|
Bmp4r
|
9.36551484046448
|
576.525518676784
|
28
|
27.173
|
1
|
1.86081812292294e-07
|
0
|
Jak_Bmp4r
|
603.698518676784
|
4.5
|
|
2
|
214
|
Jak
|
Bmp4
|
1
|
576.532783064829
|
28
|
27.165
|
1
|
1.86782326827561e-07
|
0
|
Jak_Bmp4
|
603.697783064829
|
4.5
|
|
3
|
152
|
Fgfr
|
Bmp4r
|
297.340665110465
|
582.095106272652
|
28
|
21.603
|
1
|
3.35333108014702e-06
|
0.001
|
Fgfr_Bmp4r
|
603.698106272652
|
3.58
|
|
4
|
151
|
Fgfr
|
Bmp4
|
1
|
582.105762712906
|
28
|
21.592
|
1
|
3.37201433386891e-06
|
0.001
|
Fgfr_Bmp4
|
603.697762712906
|
3.58
|
|
5
|
320
|
Raf
|
Bmp4r
|
11.8270470999121
|
583.214400670424
|
28
|
20.484
|
1
|
6.01421743351427e-06
|
0.002
|
Raf_Bmp4r
|
603.698400670424
|
3.39
|
|
6
|
319
|
Raf
|
Bmp4
|
1
|
583.214995258023
|
28
|
20.483
|
1
|
6.01608603745252e-06
|
0.002
|
Raf_Bmp4
|
603.697995258023
|
3.39
|
|
7
|
340
|
Ras
|
Bmp4
|
1
|
583.215295196378
|
28
|
20.483
|
1
|
6.01702887148559e-06
|
0.002
|
Ras_Bmp4
|
603.698295196378
|
3.39
|
|
8
|
341
|
Ras
|
Bmp4r
|
1
|
583.285700797687
|
28
|
20.412
|
1
|
6.24249802405608e-06
|
0.002
|
Ras_Bmp4r
|
603.697700797687
|
3.38
|
|
9
|
233
|
Lifr
|
Actr
|
1
|
584.389661932228
|
28
|
19.308
|
1
|
1.11215472643478e-05
|
0.004
|
Lifr_Actr
|
603.697661932228
|
3.2
|
|
10
|
250
|
Lifr
|
Smad2
|
-0.212116610255494
|
584.607072125362
|
28
|
19.091
|
1
|
1.24631310476353e-05
|
0.004
|
Lifr_Smad2
|
603.698072125362
|
3.16
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
215
|
Jak
|
Bmp4r
|
52.355777048759
|
341.656398246847
|
28
|
21.387
|
1
|
3.75296587085128e-06
|
0.001
|
Jak_Bmp4r
|
363.043398246847
|
5.89
|
|
2
|
214
|
Jak
|
Bmp4
|
1
|
341.656400962345
|
28
|
21.387
|
1
|
3.75297118637707e-06
|
0.001
|
Jak_Bmp4
|
363.043400962345
|
5.89
|
|
3
|
62
|
Akt
|
Stat3
|
-3.6354949850077
|
344.145773576097
|
28
|
18.898
|
1
|
1.37920329837948e-05
|
0.005
|
Akt_Stat3
|
363.043773576097
|
5.21
|
|
4
|
314
|
Pi3k
|
Stat3
|
-0.104722350512355
|
344.145773582876
|
28
|
18.898
|
1
|
1.37920330328667e-05
|
0.005
|
Pi3k_Stat3
|
363.043773582876
|
5.21
|
|
5
|
440
|
mTor
|
Stat3
|
-3.00146504106831
|
344.145773792024
|
28
|
18.898
|
1
|
1.37920345449905e-05
|
0.005
|
mTor_Stat3
|
363.043773792024
|
5.21
|
|
6
|
229
|
Jak
|
Smad2
|
0.192179763329023
|
344.457364986238
|
28
|
18.586
|
1
|
1.62401393908329e-05
|
0.005
|
Jak_Smad2
|
363.043364986238
|
5.12
|
|
7
|
212
|
Jak
|
Actr
|
1
|
344.497041593409
|
28
|
18.546
|
1
|
1.65817100210575e-05
|
0.006
|
Jak_Actr
|
363.043041593409
|
5.11
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Jak_Bmp4r
|
27.173
|
0
|
4.5
|
21.387
|
0.001
|
5.89
|
48.56
|
10.39
|
|
2
|
Jak_Bmp4
|
27.165
|
0
|
4.5
|
21.387
|
0.001
|
5.89
|
48.552
|
10.39
|
LA10
XX : List post filter
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
314
|
Pi3k
|
Stat3
|
-0.0376082804084924
|
324.184135168756
|
29
|
17.472
|
1
|
2.9153056752107e-05
|
0.01
|
Pi3k_Stat3
|
341.656135168756
|
5.11
|
|
2
|
62
|
Akt
|
Stat3
|
-2.97929495127255
|
324.18413520201
|
29
|
17.472
|
1
|
2.91530572621435e-05
|
0.01
|
Akt_Stat3
|
341.65613520201
|
5.11
|
|
3
|
440
|
mTor
|
Stat3
|
-2.4604910805264
|
324.184135647864
|
29
|
17.472
|
1
|
2.91530640992299e-05
|
0.01
|
mTor_Stat3
|
341.656135647864
|
5.11
|
Intersection List
Summary
Links Added and Residuals
|
|
Model_iteration
|
Links
|
res_p_01_XX
|
res_p_01_XO
|
|
1
|
Init
|
Init Network
|
2056.3
|
1603.72
|
|
2
|
1
|
Jak->Fgfr
|
1515
|
1063.56
|
|
3
|
2
|
Gsk3->Igfr
|
970.96
|
970.63
|
|
4
|
3
|
Erk->Mek
|
932.14
|
720.06
|
|
5
|
4
|
Bmp4r->Fgfr
|
798.29
|
611.48
|
|
6
|
5
|
Jak->Gsk3
|
737.94
|
547.33
|
|
7
|
6
|
Bmp4r->Smad2
|
691.87
|
465.99
|
|
8
|
7
|
Actr->Ras
|
645.08
|
422.58
|
|
9
|
8
|
Gsk3->Stat3
|
626.84
|
388.76
|
|
10
|
9
|
Lifr->Gsk3
|
603.7
|
363.04
|
|
11
|
10
|
Jak->Bmp4r
|
576.52
|
341.66
|
